Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2492180 | 0.89 | MET (0.65) | METKDM4EMAPTRECQLTDP1 | |
| SCHEMBL2495500 | 0.84 | MET (0.70) | METKDM4EMAPTRECQLTDP1 | |
| SCHEMBL13888410 | 0.79 | MET (0.78) | METKDM4EMAPTMEN1PKM | |
| SCHEMBL2266182 | 0.79 | MET (1.00) | METKDM4EMEN1PKMKMT2A | |
| SCHEMBL2495116 | 0.78 | MET (0.80) | METKDM4EMEN1PKMKMT2A | |
| SCHEMBL2499710 | 0.77 | MET (0.78) | METKDM4EMEN1PKMKMT2A | |
| SCHEMBL2496343 | 0.77 | MET (0.78) | METKDM4EMEN1PKMKMT2A | |
| SCHEMBL2492967 | 0.77 | MET (0.78) | METKDM4EMEN1PKMKMT2A | |
| SCHEMBL2498143 | 0.77 | MET (0.73) | METKDM4EMEN1PKMKMT2A | |
| SCHEMBL5557932 | 0.75 | MET (0.75) | METKDM4EMEN1PKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-B1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-02 | — | — | EP | disclosed |
| US-9090614-B2 | Processes and intermediates for producing azaindoles | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-07-28 | — | — | US | disclosed |