Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.84 |
| ▸ | GAA | P10253 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 6/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.63 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6127192 | 0.86 | KDM4E (0.89) | KDM4EGAANPC1CYP1A2CYP2C9 | |
| SCHEMBL4045277 | 0.85 | KDM4E (0.81) | KDM4EGAANPC1CYP1A2CYP2C9 | |
| SCHEMBL8443436 | 0.84 | KDM4E (0.84) | KDM4EGAANPC1CYP1A2CYP2C9 | |
| SCHEMBL5246151 | 0.84 | KDM4E (0.78) | KDM4EGAANPC1CYP1A2CYP2C9 | |
| SCHEMBL18906066 | 0.83 | KDM4E (0.83) | KDM4EGAANPC1CYP1A2CYP2C9 | |
| SCHEMBL1935628 | 0.83 | GAA (1.00) | KDM4EGAANPC1CYP1A2CYP2C9 | |
| SCHEMBL6928579 | 0.83 | KDM4E (0.76) | KDM4EGAANPC1CYP1A2CYP2C9 | |
| SCHEMBL28992962 | 0.82 | KDM4E (0.81) | KDM4EGAANPC1CYP1A2CYP2C9 | |
| SCHEMBL11484833 | 0.82 | KDM4E (0.81) | KDM4EGAANPC1CYP1A2CYP2C9 | |
| SCHEMBL12181187 | 0.82 | KDM4E (0.81) | KDM4EGAANPC1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-B1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-02 | — | — | EP | disclosed |