Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.61 |
| ▸ | NQO2 | P16083 | 1/20 | 0.61 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.61 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1163158 | 0.83 | MET (0.71) | METPDE3ANQO2PDE3BPIP4K2C | |
| SCHEMBL2697192 | 0.80 | MET (1.00) | METPDE3ANQO2PDE3BPIP4K2C | |
| SCHEMBL9910501 | 0.79 | MET (0.86) | METPDE3ANQO2PDE3BPIP4K2C | |
| Jnj-38877618 SCHEMBL29391956 | 0.79 | MET (0.86) | METPDE3ANQO2PDE3BPIP4K2C | |
| SCHEMBL9910502 | 0.79 | MET (0.86) | METPDE3ANQO2PDE3BPIP4K2C | |
| Jnj-38877618 SCHEMBL2492511 | 0.79 | MET (0.86) | METPDE3ANQO2PDE3BPIP4K2C | |
| Jnj-38877618 SCHEMBL29483371 | 0.79 | MET (0.86) | METPDE3ANQO2PDE3BPIP4K2C | |
| SCHEMBL12049490 | 0.79 | MET (0.84) | METPDE3ANQO2PDE3BPIP4K2C | |
| SCHEMBL1163405 | 0.79 | MET (0.74) | METPDE3ANQO2PDE3BPIP4K2C | |
| SCHEMBL17768402 | 0.79 | MET (0.74) | METPDE3ANQO2PDE3BPIP4K2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-B9 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-13 | — | — | EP | disclosed |
| EP-1966214-B1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-02 | — | — | EP | disclosed |