SCHEMBL18200475

SCHEMBL18200475

c1ccc(-c2ccc(-c3nc4ccccc4c4c3ccc3ccccc34)cn2)nc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGDS O60760 1/20 0.41
DHODH Q02127 1/20 0.40
METAP1 P53582 5/20 0.39
AHR P35869 1/20 0.39
NPC1 O15118 3/20 0.37
ALDH1A1 P00352 3/20 0.37
LMNA P02545 3/20 0.37
CYP2C9 P11712 2/20 0.37
RAB9A P51151 2/20 0.37
HIF1A Q16665 2/20 0.37
HTT P42858 2/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
GAA P10253 1/20 0.37
KDM4E B2RXH2 4/20 0.36
MAPT P10636 2/20 0.36
TP53 P04637 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
HPGD P15428 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
CYP1A2 P05177 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18200608 0.95 HPGDS (0.40) HPGDSDHODHMETAP1AHRNPC1
SCHEMBL18200716 0.94 METAP1 (0.45) METAP1NPC1ALDH1A1LMNARAB9A
SCHEMBL18346940 0.93 DHODH (0.46) HPGDSDHODHMETAP1AHRNPC1
SCHEMBL18346941 0.91 DHODH (0.44) HPGDSDHODHMETAP1AHRNPC1
SCHEMBL18200607 0.88 DHODH (0.48) DHODHMETAP1AHRNPC1ALDH1A1
SCHEMBL18201113 0.88 MAPT (0.40) HPGDSDHODHNPC1ALDH1A1LMNA
SCHEMBL18200375 0.87 METAP1 (0.43) HPGDSMETAP1NPC1ALDH1A1LMNA
SCHEMBL18200680 0.86 MAPT (0.40) NPC1ALDH1A1LMNARAB9AL3MBTL1
SCHEMBL23081859 0.86 DHODH (0.44) HPGDSDHODHMETAP1AHRNPC1
SCHEMBL18200386 0.85 METAP1 (0.43) DHODHMETAP1AHRNPC1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3088392-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING SAME Heesung Material Ltd. (KR) 2016-11-02 EP disclosed