Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 5/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 4/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.43 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.39 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CCR9 | P51686 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1801399 | 0.87 | TP53 (0.44) | ERAP1TP53PTPN2PTPN1PTPN5 | |
| SCHEMBL5609111 | 0.86 | TP53 (0.46) | ERAP1TP53PTPN2PTPN1PTPN5 | |
| SCHEMBL3911560 | 0.84 | PTPN2 (0.45) | ERAP1TP53PTPN2PTPN1PTPN5 | |
| SCHEMBL3906902 | 0.75 | ERAP1 (0.44) | ERAP1TP53PTPN2PTPN1PTPN5 | |
| SCHEMBL3906955 | 0.74 | PTPN2 (0.43) | ERAP1TP53PTPN2PTPN1PTPN5 | |
| SCHEMBL3916191 | 0.74 | PTPN2 (0.43) | ERAP1TP53PTPN2PTPN1PTPN5 | |
| SCHEMBL1804773 | 0.73 | MEN1 (0.46) | LMNATHRBMAPTPKMHTT | |
| SCHEMBL1843321 | 0.73 | FFAR4 (0.43) | ERAP1TP53PTPN2PTPN1PTPN5 | |
| SCHEMBL3908576 | 0.73 | PTPN2 (0.42) | ERAP1TP53PTPN2PTPN1PTPN5 | |
| SCHEMBL1812321 | 0.73 | PTPN2 (0.49) | ERAP1TP53PTPN2PTPN1PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4682207-B2 | — | — | 2011-05-11 | — | — | JP | claimed |
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | claimed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | claimed |