Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.40 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PRF1 | P14222 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5617634 | 0.87 | MEN1 (0.49) | LMNATHRBMAPTHTR6KMT2A | |
| SCHEMBL1820048 | 0.86 | ERAP1 (0.46) | TP53ERAP1LMNATHRBMAPT | |
| SCHEMBL3915268 | 0.85 | TP53 (0.46) | TP53ERAP1LMNATHRBMAPT | |
| SCHEMBL1801399 | 0.83 | TP53 (0.44) | TP53ERAP1LMNATHRBMAPT | |
| SCHEMBL5617460 | 0.74 | PFKFB3 (0.41) | TP53LMNATHRBMAPTHTR6 | |
| SCHEMBL3911560 | 0.72 | PTPN2 (0.45) | TP53ERAP1LMNATHRBMAPT | |
| SCHEMBL3905681 | 0.72 | MEN1 (0.49) | TP53LMNATHRBMAPTHTR6 | |
| SCHEMBL3906955 | 0.72 | PTPN2 (0.43) | TP53ERAP1LMNATHRBMAPT | |
| SCHEMBL5608712 | 0.72 | BRD4 (0.46) | LMNATHRBHTR6KMT2ABRD4 | |
| SCHEMBL3906902 | 0.72 | ERAP1 (0.44) | TP53ERAP1LMNATHRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | disclosed |