SCHEMBL18201577

SCHEMBL18201577

CC(C)(O)CCCc1cccc(N)c1

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.52
MAOA P21397 2/20 0.52
CYP19A1 P11511 1/20 0.50
SIGMAR1 Q99720 2/20 0.44
GRM2 Q14416 1/20 0.43
GRM3 Q14832 1/20 0.43
HMGCR P04035 1/20 0.41
VDR P11473 3/20 0.38
CYP3A4 P08684 1/20 0.37
CASP1 P29466 1/20 0.37
RECQL P46063 1/20 0.37
NOS1 P29475 1/20 0.37
MAPT P10636 1/20 0.36
CYP24A1 Q07973 1/20 0.36
PARP1 P09874 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5086046 0.89 MAOA (0.55) MAOBMAOACYP19A1SIGMAR1GRM2
SCHEMBL11204314 0.86 MAOB (0.55) MAOBMAOACYP19A1SIGMAR1GRM2
SCHEMBL15782885 0.81 TAAR1 (0.52) GRM2GRM3HMGCR
SCHEMBL14341098 0.80 MAOB (0.50) MAOBMAOACYP19A1GRM2GRM3
SCHEMBL6292536 0.79 TAAR1 (0.50) MAOBSIGMAR1HMGCRVDR
SCHEMBL29437072 0.79 MAOB (0.71) MAOBMAOACYP19A1SIGMAR1GRM2
SCHEMBL18045550 0.79 MAOB (0.71) MAOBMAOACYP19A1SIGMAR1CYP3A4
SCHEMBL29436975 0.79 MAOB (0.71) MAOBMAOACYP19A1SIGMAR1CYP3A4
SCHEMBL1026806 0.79 MAOB (0.71) MAOBMAOACYP19A1SIGMAR1GRM2
SCHEMBL14762228 0.78 MAOB (0.59) MAOBMAOACYP19A1SIGMAR1GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2928886-B1 NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS BOEHRINGER INGELHEIM INT (DE) 2016-11-02 EP disclosed