Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1976892 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2LMNAPOLBGBA2BCHE | |
| SCHEMBL1975655 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2LMNAPOLBGBA2BCHE | |
| SCHEMBL1972893 | 0.92 | CYP2D6 (0.34) | SMN1; SMN2GBA2KMT2ATP53CYP2D6 | |
| SCHEMBL1819283 | 0.92 | CYP2D6 (0.34) | SMN1; SMN2GBA2KMT2ATP53CYP2D6 | |
| SCHEMBL1974127 | 0.92 | CYP2D6 (0.34) | SMN1; SMN2GBA2KMT2ATP53CYP2D6 | |
| SCHEMBL1821719 | 0.88 | CYP2D6 (0.42) | L3MBTL1KMT2AALDH1A1CYP2D6 | |
| SCHEMBL1976076 | 0.88 | CYP2D6 (0.42) | L3MBTL1KMT2AALDH1A1CYP2D6 | |
| SCHEMBL1974539 | 0.88 | CYP2D6 (0.42) | L3MBTL1KMT2AALDH1A1CYP2D6 | |
| SCHEMBL30872362 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAPOLBGBA2BCHE | |
| SCHEMBL1691950 | 0.81 | CYP2D6 (0.41) | SMN1; SMN2L3MBTL1KMT2AALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315748-B1 | PROCESSES FOR THE PREPARATION OF 4-OXO-OCTAHYDRO-INDOLE-1-CARBOCYLIC ACID METHYL ESTER AND DERIVATIVES THEREOF | NOVARTIS AG (CH) | 2015-06-24 | — | — | EP | disclosed |
| US-8084487-B2 | Processes for the preparation of 4-oxo-octahydro-indole-1-carbocyclic acid methyl ester and derivatives thereof | NOVARTIS AG (CH) | 2011-12-27 | — | — | US | disclosed |
| US-20110144352-A1 | PROCESSES FOR THE PREPARATION OF 4-OXO-OCTAHYDRO-INDOLE-1-CARBOCYCLIC ACID METHYL ESTER AND DERIVATIVES THEREOF | NOVARTIS AG (CH) | 2011-06-16 | — | — | US | disclosed |
| EP-2315748-A1 | PROCESSES FOR THE PREPARATION OF 4-OXO-OCTAHYDRO-INDOLE-1-CARBOCYLIC ACID METHYL ESTER AND DERIVATIVES THEREOF | Novartis AG (CH) | 2011-05-04 | — | — | EP | disclosed |
| WO-2010018154-A1 | PROCESSES FOR THE PREPARATION OF 4-OXO-OCTAHYDRO-INDOLE-1-CARBOCYLIC ACID METHYL ESTER AND DERIVATIVES THEREOF | NOVARTIS AG (CH) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144352-A1 | PROCESSES FOR THE PREPARATION OF 4-OXO-OCTAHYDRO-INDOLE-1-CARBOCYCLIC ACID METHYL ESTER AND DERIVATIVES THEREOF | KMO, IDO1, ALKBH3 | SMN1; SMN2 4231/4885LMNA 3636/4885POLB 3853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.