SCHEMBL18202076

SCHEMBL18202076

COc1cc(-c2cc(OC)cc(C(C)(C)C)c2OP(Cl)Cl)c(OC(=O)C(C)(C)C)c(C(C)(C)C)c1

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
VCAM1 P19320 4/20 0.33
TNFRSF1A P19438 1/20 0.33
ELANE P08246 8/20 0.33
ALDH1A1 P00352 1/20 0.31
GAA P10253 1/20 0.31
NR1H4 Q96RI1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17270586 0.88 CA1 (0.47) CA1CA2VCAM1TNFRSF1A
SCHEMBL18202075 0.85 CA1 (0.54) CA1CA2VCAM1TNFRSF1AELANE
SCHEMBL17267257 0.85 CA1 (0.41) CA1CA2VCAM1TNFRSF1AELANE
SCHEMBL17285536 0.83 CA1 (0.49) CA1CA2TNFRSF1AALDH1A1GAA
SCHEMBL10789476 0.79 CA1 (0.57) CA1CA2VCAM1TNFRSF1AALDH1A1
SCHEMBL7149136 0.78 CA1 (0.49) CA1CA2TNFRSF1AALDH1A1GAA
SCHEMBL18950756 0.77 CA1 (0.37) CA1CA2VCAM1TNFRSF1AELANE
SCHEMBL4369204 0.75 CA2 (0.54) CA1CA2VCAM1TNFRSF1AALDH1A1
SCHEMBL9192342 0.74 CA1 (0.52) CA1CA2TNFRSF1AALDH1A1GAA
SCHEMBL17270588 0.74 CA1 (0.57) CA1CA2VCAM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3088407-A1 NOVEL MONOPHOSPHIT COMPOUNDS WITH AN ESTER GROUP Evonik Degussa GmbH (DE) 2016-11-02 EP disclosed