Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 6/20 | 0.40 |
| ▸ | CACNG8 | Q8WXS5 | 6/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18190747 | 0.92 | ABCB11 (0.44) | GRIA1CACNG8ABCB11METPDE3B | |
| SCHEMBL18190578 | 0.80 | TP53 (0.46) | GRIA1CACNG8PDE3BPDE3ASCN9A | |
| SCHEMBL18190773 | 0.78 | ABL1 (0.48) | GRIA1CACNG8PDE3BPDE3AABL1 | |
| SCHEMBL18190482 | 0.72 | GRIA1 (0.53) | GRIA1CACNG8PDE3BPDE3AABL1 | |
| SCHEMBL18190566 | 0.71 | GRIA1 (0.59) | GRIA1CACNG8PDE3BPDE3ATERT | |
| SCHEMBL18190734 | 0.71 | GRIA1 (0.69) | GRIA1CACNG8 | |
| SCHEMBL18190613 | 0.71 | GRIA1 (0.53) | GRIA1CACNG8PDE3BPDE3ADYRK1A | |
| SCHEMBL18190548 | 0.69 | GRIA1 (0.53) | GRIA1CACNG8PDE3BPDE3ADYRK1A | |
| SCHEMBL18190607 | 0.69 | PRMT5 (0.47) | GRIA1CACNG8PDE3BPDE3AABL1 | |
| SCHEMBL18190714 | 0.68 | GRIA1 (0.50) | GRIA1CACNG8METPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016176449-A1 | BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-03 | — | — | WO | disclosed |