Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.43 |
| ▸ | AURKA | O14965 | 4/20 | 0.42 |
| ▸ | TPX2 | Q9ULW0 | 4/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28025049 | 0.90 | P2RX7 (0.44) | P2RX7AURKATPX2CSNK2A2CSNK2B | |
| SCHEMBL18203954 | 0.85 | P2RX7 (0.41) | P2RX7AURKATPX2 | |
| SCHEMBL18203922 | 0.82 | P2RX7 (0.46) | P2RX7AURKATPX2KDM4EMEN1 | |
| SCHEMBL15797379 | 0.77 | AURKA (0.58) | P2RX7AURKATPX2CSNK2A2CSNK2B | |
| SCHEMBL18203887 | 0.77 | P2RX7 (0.44) | P2RX7AURKATPX2 | |
| SCHEMBL15797513 | 0.73 | P2RX7 (0.54) | P2RX7AURKATPX2GAAMAPT | |
| SCHEMBL28025050 | 0.73 | P2RX7 (0.46) | P2RX7AURKATPX2KDM4EALDH1A1 | |
| SCHEMBL18204116 | 0.73 | P2RX7 (0.39) | P2RX7AURKATPX2CSNK2A2CSNK2B | |
| SCHEMBL18203921 | 0.72 | P2RX7 (0.47) | P2RX7AURKATPX2KDM4EALDH1A1 | |
| SCHEMBL20939366 | 0.72 | P2RX7 (0.42) | P2RX7AURKATPX2PRKCQPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935211-B1 | INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-11-09 | — | — | EP | claimed |