Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 3/20 | 0.71 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 7/20 | 0.58 |
| ▸ | RAB9A | P51151 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | SCD | O00767 | 4/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16896934 | 1.00 | ACP1 (0.71) | ACP1DYRK1ANPC1RAB9AMAPT | |
| SCHEMBL18205120 | 0.87 | ACP1 (0.72) | ACP1DYRK1ANPC1RAB9AMAPT | |
| SCHEMBL18205118 | 0.87 | ACP1 (0.72) | ACP1DYRK1ANPC1RAB9AMAPT | |
| SCHEMBL2753558 | 0.84 | ACP1 (0.68) | ACP1DYRK1ANPC1RAB9AMAPT | |
| SCHEMBL19844519 | 0.83 | ACP1 (0.61) | ACP1DYRK1ANPC1RAB9AMAPT | |
| SCHEMBL18289904 | 0.83 | ACP1 (1.00) | ACP1DYRK1ANPC1RAB9AMAPT | |
| SCHEMBL19844515 | 0.83 | ACP1 (0.61) | ACP1DYRK1ANPC1RAB9AMAPT | |
| SCHEMBL2891915 | 0.79 | ACP1 (0.62) | ACP1DYRK1ANPC1RAB9AMAPT | |
| SCHEMBL5713530 | 0.79 | MAP3K5 (0.75) | DYRK1ANPC1RAB9AMAPTOPRK1 | |
| SCHEMBL19844508 | 0.79 | DYRK1A (0.61) | ACP1DYRK1ANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944648-B2 | Organic compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2018-04-17 | — | — | US | disclosed |
| US-20170190703-A9 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2017-07-06 | — | — | US | disclosed |
| US-20160326179-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2016-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190703-A9 | ORGANIC COMPOUNDS | PSEN1, CKMT1A; CKMT1B, GSK3A | ACP1 70/4885DYRK1A 1301/4885NPC1 396/4885 |
| US-20160326179-A1 | ORGANIC COMPOUNDS | PSEN1, CKMT1A; CKMT1B, GSK3A | ACP1 70/4885DYRK1A 1301/4885NPC1 396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.