Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.75 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.72 |
| ▸ | NPC1 | O15118 | 7/20 | 0.71 |
| ▸ | RAB9A | P51151 | 7/20 | 0.71 |
| ▸ | SCD | O00767 | 5/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 4/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.67 |
| ▸ | RELA | Q04206 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13329390 | 0.92 | MAP3K5 (0.83) | MAP3K5LRRK2NPC1RAB9ASCD | |
| SCHEMBL12199516 | 0.89 | MAP3K5 (0.68) | MAP3K5LRRK2NPC1RAB9ASCD | |
| SCHEMBL12199489 | 0.89 | MAP3K5 (0.68) | MAP3K5LRRK2NPC1RAB9ASCD | |
| SCHEMBL17916689 | 0.88 | SCD (0.67) | MAP3K5LRRK2NPC1RAB9ASCD | |
| Bromide SCHEMBL2482871 | 0.88 | MAP3K5 (0.67) | MAP3K5LRRK2NPC1RAB9ASCD | |
| SCHEMBL2483622 | 0.88 | MAP3K5 (0.77) | MAP3K5LRRK2NPC1RAB9ASCD | |
| SCHEMBL21681916 | 0.87 | MAP3K5 (0.69) | MAP3K5LRRK2NPC1RAB9ASCD | |
| SCHEMBL12199508 | 0.87 | SCD (0.65) | MAP3K5LRRK2NPC1RAB9ASCD | |
| SCHEMBL12199335 | 0.87 | MAP3K5 (0.76) | MAP3K5LRRK2NPC1RAB9ASCD | |
| SCHEMBL12225800 | 0.87 | MAP3K5 (0.76) | MAP3K5LRRK2NPC1RAB9ASCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100420678-C | Cyclization process for substituted benzothiazole derivatives | HOFFMANN LA ROCHE (CH) | 2008-09-24 | — | — | CN | disclosed |
| EP-1583752-B1 | CYCLIZATION PROCESS FOR SUBSTITUTED BENZOTHIAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-08-16 | — | — | EP | disclosed |
| US-7087761-B2 | Cyclization process for substituted benzothiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-08-08 | — | — | US | disclosed |
| CN-1738808-A | Cyclization process for substituted benzothiazole derivatives | HOFFMANN LA ROCHE (CH) | 2006-02-22 | — | — | CN | disclosed |
| EP-1583752-A2 | CYCLIZATION PROCESS FOR SUBSTITUTED BENZOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004060879-A2 | CYCLIZATION PROCESS FOR SUBSTITUTED BENZOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-22 | — | — | WO | disclosed |
| US-20040138465-A1 | Cyclization process for substituted benzothiazole derivatives | HOFFMANN-LA ROCHE INC. | 2004-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138465-A1 | Cyclization process for substituted benzothiazole derivatives | CBR3, CBR1, OXTR | MAP3K5 3724/4885LRRK2 2042/4885NPC1 962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.