Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1818750 | 1.00 | GAA (0.46) | GAAALDH1A1SMN1; SMN2KEAP1KDM4E | |
| SCHEMBL2015998 | 1.00 | GAA (0.46) | GAAALDH1A1SMN1; SMN2KEAP1KDM4E | |
| SCHEMBL2011097 | 1.00 | GAA (0.46) | GAAALDH1A1SMN1; SMN2KEAP1KDM4E | |
| SCHEMBL17518331 | 0.80 | GAA (0.47) | GAAALDH1A1SMN1; SMN2KEAP1KDM4E | |
| SCHEMBL17518251 | 0.79 | GAA (0.46) | GAAALDH1A1SMN1; SMN2KEAP1KDM4E | |
| SCHEMBL2201068 | 0.78 | GAA (0.57) | GAAALDH1A1SMN1; SMN2KEAP1KDM4E | |
| SCHEMBL17518390 | 0.75 | GAA (0.48) | GAAALDH1A1SMN1; SMN2KEAP1KDM4E | |
| SCHEMBL6472014 | 0.75 | GAA (0.50) | GAAALDH1A1SMN1; SMN2KEAP1KDM4E | |
| SCHEMBL14562932 | 0.74 | ALDH1A1 (0.50) | GAAALDH1A1SMN1; SMN2KEAP1KDM4E | |
| SCHEMBL4405073 | 0.74 | ALDH1A1 (0.50) | GAAALDH1A1SMN1; SMN2KEAP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498782-A1 | CRYSTALLINE FORMS OF NEUROTROPHIN MIMETIC COMPOUNDS AND THEIR SALTS | Pharmatrophix Inc. (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011060262-A1 | CRYSTALLINE FORMS OF NEUROTROPHIN MIMETIC COMPOUNDS AND THEIR SALTS | PHARMATROPHIX, INC. (US) | 2011-05-19 | — | — | WO | disclosed |