Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mequitazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 2/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 2/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | HTR2A | P28223 | 2/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | HTR2B | P41595 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | EGFR | P00533 | 1/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mequitazine SCHEMBL29376901 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ACHRM1ADRA2B | |
| Mequitazine SCHEMBL604639 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ACHRM1ADRA2B | |
| Mequitazine SCHEMBL18207 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ACHRM1ADRA2B | |
| Mequitazine SCHEMBL29382350 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ACHRM1ADRA2B | |
| Mequitazine SCHEMBL605366 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ACHRM1ADRA2B | |
| Mequitazine SCHEMBL29379090 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ACHRM1ADRA2B | |
| Mequitazine SCHEMBL11973309 | 0.99 | CYP2D6 (0.97) | CYP2D6CHRM2ADRA2ACHRM1ADRA2B | |
| Mequitazine SCHEMBL28086297 | 0.89 | CYP2D6 (0.79) | CYP2D6CHRM2ADRA2ACHRM1ADRA2B | |
| SCHEMBL23954312 | 0.86 | MAPT (0.74) | CYP2D6CHRM2ADRA2ACHRM1ADRA2B | |
| Oxomemazine SCHEMBL28086314 | 0.77 | CYP2D6 (0.60) | CYP2D6CHRM2ADRA2ACHRM1ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5593 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| EP-4704971-A1 | GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY | Cognito Therapeutics, Inc. (US) | 2026-03-11 | — | — | EP | claimed |
| US-12569451-B2 | Bio-inspired tissue-adhesive hydrogel patch and uses thereof | Cellartgen Inc. (KR) | 2026-03-10 | — | — | US | claimed |
| EP-4691492-A2 | LIQUID COMPOSITIONS | Kenvue Brands LLC (US) | 2026-02-11 | — | — | EP | claimed |
| WO-2025111482-A1 | COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS | BEXSON BIOMEDICAL, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| WO-2025082959-A1 | A PHENOTHIAZINE-RELATED COMPOUND CONJUGATED TO A PEPTIDE | UNIVERSITY OF ULSTER (GB) | 2025-04-24 | — | — | WO | claimed |
| CN-114072132-B | Bionic tissue adhesive hydrogel patch and application thereof | 赛拉尔研究有限公司 | 2024-11-15 | — | — | CN | claimed |
| WO-2024229174-A1 | GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY | Cognito Therapeutics, Inc. (US) | 2024-11-07 | — | — | WO | claimed |
| CN-112368300-B | SPNS2 neutralizing antibodies | 帝人制药株式会社 | 2024-10-01 | — | — | CN | claimed |
| CN-118647367-A | Novel injectable combination formulations | 南爱克萨股份公司 | 2024-09-13 | — | — | CN | claimed |
| US-5019591-A | Antihistamines | PENNSYLVANIA RESEARCH CORPORATION (US) | 1991-05-28 | — | — | US | claimed |
| EP-0402422-A1 | CERTAIN PAF ANTAGONIST ANTIHISTAMINE COMBINATIONS AND METHODS | SCHERING CORPORATION (US) | 1990-12-19 | — | — | EP | claimed |
| EP-0345931-A1 | Certain PAF antagonist/antihistamine combinations and methods | SCHERING CORPORATION (US) | 1989-12-13 | — | — | EP | claimed |
| WO-1989010143-A1 | CERTAIN PAF ANTAGONIST ANTIHISTAMINE COMBINATIONS AND METHODS | SCHERING CORPORATION (US) | 1989-11-02 | — | — | WO | claimed |
| EP-0316434-A4 | COUGH/COLD MIXTURES COMPRISING NON-SEDATING ANTIHISTAMINE DRUGS. | SUNSHINE ABRAHAM (US) | 1989-10-16 | — | — | EP | claimed |
| US-4871733-A | WITH NON-STEROIDAL ANTIINFLAMMATORY | ANALGESIC ASSOCIATES (US) | 1989-10-03 | — | — | US | claimed |
| EP-0316434-A1 | COUGH/COLD MIXTURES COMPRISING NON-SEDATING ANTIHISTAMINE DRUGS. | SUNSHINE ABRAHAM (US) | 1989-05-24 | — | — | EP | claimed |
| EP-0311677-A1 | COUGH/COLD MIXTURES COMPRISING NON-SEDATING ANTIHISTAMINE DRUGS. | SUNSHINE ABRAHAM (US) | 1989-04-19 | — | — | EP | claimed |
| WO-1988009656-A1 | COUGH/COLD MIXTURES COMPRISING NON-SEDATING ANTIHISTAMINE DRUGS | SUNSHINE ABRAHAM (US) | 1988-12-15 | — | — | WO | claimed |
| WO-1988008302-A1 | COUGH/COLD MIXTURES COMPRISING NON-SEDATING ANTIHISTAMINE DRUGS | SUNSHINE ABRAHAM (US) | 1988-11-03 | — | — | WO | claimed |