Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxomemazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.60 |
| ▸ | DRD1 | P21728 | 6/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.60 |
| ▸ | DRD3 | P35462 | 6/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.60 |
| ▸ | HTR1A | P08908 | 5/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.60 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.60 |
| ▸ | HTR2A | P28223 | 3/20 | 0.60 |
| ▸ | HTR2B | P41595 | 3/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mequitazine SCHEMBL29379090 | 0.77 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Mequitazine SCHEMBL29376901 | 0.77 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Mequitazine SCHEMBL605366 | 0.77 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Mequitazine SCHEMBL18208 | 0.77 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Mequitazine SCHEMBL18207 | 0.77 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Mequitazine SCHEMBL29382350 | 0.77 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Mequitazine SCHEMBL604639 | 0.77 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Mequitazine SCHEMBL11973309 | 0.76 | CYP2D6 (0.97) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Oxomemazine SCHEMBL423634 | 0.76 | LMNA (0.60) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Oxomemazine SCHEMBL29378205 | 0.76 | LMNA (0.60) | CYP2D6CHRM2ADRA2ACHRM1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |