Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 1/20 | 0.60 |
| ▸ | NPY2R | P49146 | 1/20 | 0.60 |
| ▸ | NPY4R | P50391 | 1/20 | 0.60 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.60 |
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL270820 | 1.00 | NPY1R (0.60) | NPY1RNPY2RNPY4RNPY5RACACB | |
| SCHEMBL11937222 | 0.98 | NPY1R (0.62) | NPY1RNPY2RNPY4RNPY5RACACB | |
| SCHEMBL16437278 | 0.94 | NPY1R (0.57) | NPY1RNPY2RNPY4RNPY5RACACB | |
| SCHEMBL12169265 | 0.90 | NPY1R (0.56) | NPY1RNPY2RNPY4RNPY5RACACB | |
| SCHEMBL6135358 | 0.89 | NPY1R (0.47) | NPY1RNPY2RNPY4RNPY5RACACB | |
| SCHEMBL4964678 | 0.89 | NPY1R (0.47) | NPY1RNPY2RNPY4RNPY5RACACB | |
| SCHEMBL13403331 | 0.85 | NPY1R (0.51) | NPY1RNPY2RNPY4RNPY5RACACB | |
| SCHEMBL2242868 | 0.83 | PARP10 (0.55) | ALDH1A1HPGDPARP10HRH3TSHR | |
| SCHEMBL13110232 | 0.83 | NPY1R (0.50) | NPY1RNPY2RNPY4RNPY5RACACB | |
| SCHEMBL13110259 | 0.83 | NPY1R (0.50) | NPY1RNPY2RNPY4RNPY5RACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9486422-B2 | Small molecule inhibitors of Mcl-1 and the uses of thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-11-08 | — | — | US | disclosed |