⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5841454 | 0.94 | LMNA (0.69) | — | |
| SCHEMBL5841186 | 0.91 | TSHR (0.71) | — | |
| SCHEMBL9034003 | 0.91 | TSHR (0.71) | — | |
| Glutarate SCHEMBL8618878 | 0.87 | SLC22A6 (0.92) | — | |
| Glutarate SCHEMBL27601182 | 0.83 | SLC22A6 (1.00) | — | |
| Glutarate SCHEMBL158774 | 0.83 | SLC22A6 (1.00) | — | |
| Glutarate SCHEMBL6701735 | 0.83 | — | — | |
| Glutarate SCHEMBL7414 | 0.83 | — | — | |
| SCHEMBL1498152 | 0.80 | — | — | |
| Glutarate SCHEMBL104915 | 0.79 | SLC22A6 (0.92) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7138530-B2 | Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-11-21 | — | — | US | claimed |
| EP-1549632-A4 | NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS | DIMENSIONAL PHARM INC (US) | 2005-11-09 | — | — | EP | claimed |
| US-20050234081-A1 | Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions | SUBASINGHE NALIN | 2005-10-20 | — | — | US | claimed |
| EP-1549632-A1 | NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-07-06 | — | — | EP | claimed |
| US-20040009995-A1 | Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2004-01-15 | — | — | US | claimed |
| WO-2003099805-A1 | NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2003-12-04 | — | — | WO | claimed |
| EP-0469919-B1 | A process for the enzymatic preparation of 7-aminocephalosporanic acid | ANTIBIOTICOS SPA (IT) | 1997-04-09 | — | — | EP | claimed |
| US-5354667-A | Use of recombinant DNA techniques | ANTIBIOTICOS, S.P.A. (IT) | 1994-10-11 | — | — | US | claimed |
| EP-0469919-A2 | A process for the enzymatic preparation of 7-aminocephalosporanic acid | ANTIBIOTICOS, S.p.A. (IT) | 1992-02-05 | — | — | EP | claimed |
| US-3976546-A | HYDROLYSIS, ESTERASE | GLAXO LABORATORIES LIMITED (EN) | 1976-08-24 | — | — | US | claimed |
| JP-52128295-A | — | — | None | — | — | JP | disclosed |
| JP-63074488-A | — | — | None | — | — | JP | disclosed |
| US-9587129-B2 | Ink composition and ink set | SEIKO EPSON CORPORATION (JP) | 2017-03-07 | — | — | US | disclosed |
| US-20160137859-A1 | INK COMPOSITION AND INK SET | SEIKO EPSON CORPORATION (JP) | 2016-05-19 | — | — | US | disclosed |
| US-20160032125-A1 | INK SET | SEIKO EPSON CORPORATION (JP) | 2016-02-04 | — | — | US | disclosed |
| US-4242449-A | 7-Methoxy cephalosporins and process of producing them | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1980-12-30 | — | — | US | disclosed |
| US-4164447-A | TRANSFERS A CARBAMOYL GROUP TO 3-HYDROXYMETHYL CEPHALOSPORIN | GLAXO LABORATORIES LIMITED (GB) | 1979-08-14 | — | — | US | disclosed |
| US-4144391-A | REPLACING AN ACETOXY GROUP BY A SULFUR NUCLEOPHILE | ELI LILLY AND COMPANY (US) | 1979-03-13 | — | — | US | disclosed |
| JP-S52128295-A | PREPARATION OF CEPHALOSPORINS | TOYO JOZO CO LTD | 1977-10-27 | — | — | JP | disclosed |
| US-3976546-A | HYDROLYSIS, ESTERASE | GLAXO LABORATORIES LIMITED (EN) | 1976-08-24 | — | — | US | disclosed |