Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 7/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16548308 | 1.00 | CASR (0.47) | CASRL3MBTL1PTGS2PTGS1NR3C1 | |
| Hydrochloric Acid SCHEMBL17939920 | 0.99 | CASR (0.46) | CASRL3MBTL1PTGS2PTGS1NR3C1 | |
| SCHEMBL18215340 | 0.89 | CASR (0.45) | CASRL3MBTL1NR3C1MAPK1PFKFB3 | |
| SCHEMBL16548293 | 0.89 | CASR (0.45) | CASRL3MBTL1NR3C1MAPK1PFKFB3 | |
| Hydrochloric Acid SCHEMBL17939846 | 0.88 | CASR (0.45) | CASRL3MBTL1MAPK1PFKFB3 | |
| SCHEMBL16548305 | 0.85 | KIT (0.39) | CASRHPGDPFKFB3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL17939951 | 0.84 | KIT (0.39) | CASRHPGDMAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL16540027 | 0.82 | CASR (0.41) | CASRL3MBTL1PTGS2PTGS1NR3C1 | |
| SCHEMBL17945888 | 0.81 | PTGER4 (0.41) | CASRMAPK1 | |
| SCHEMBL17945094 | 0.81 | GRM2 (0.40) | CASRSMN1; SMN2PFKFB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493396-B2 | Substituted naphthalene compounds as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-11-15 | — | — | US | disclosed |