Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 4/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25070666 | 0.92 | — | — | |
| SCHEMBL25070429 | 0.91 | RARB (0.35) | RARBGCGRS1PR1S1PR3MMP2 | |
| SCHEMBL18217286 | 0.89 | RARB (0.34) | RARBGCGR | |
| SCHEMBL20176725 | 0.88 | RARB (0.45) | RARBGCGRS1PR1S1PR3 | |
| SCHEMBL18217177 | 0.88 | — | — | |
| SCHEMBL18418561 | 0.88 | RARB (0.39) | RARBGCGRS1PR1S1PR3MMP2 | |
| SCHEMBL25070514 | 0.86 | — | — | |
| SCHEMBL25070510 | 0.85 | — | — | |
| SCHEMBL25070338 | 0.84 | — | — | |
| SCHEMBL25070488 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738240-B2 | Thiadiazoloquinoxaline derivatives | MERCK PATENT GMBH (DE) | 2020-08-11 | — | — | US | disclosed |
| US-20180142153-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-24 | — | — | US | disclosed |
| US-20180142153-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-24 | — | — | US | disclosed |
| WO-2016177449-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-11-10 | — | — | WO | disclosed |