Sugi Predict

Sugi Predict / Compounds / SCHEMBL18220187

SCHEMBL18220187

SCHEMBL18220187

COCCNS(=O)(=O)/C(C#N)=C/c1ccc(-c2ccc3cc(N4CCN(C)CC4)ccc3c2)n1C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ APP P05067 3/20 0.47
▸ RXFP1 Q9HBX9 3/20 0.37
▸ ALDH1A1 P00352 3/20 0.35
▸ MAPT P10636 3/20 0.35
▸ PRKD1 Q15139 1/20 0.35
▸ ATM Q13315 1/20 0.35
▸ KMT2A Q03164 6/20 0.34
▸ MEN1 O00255 5/20 0.34
▸ NPC1 O15118 2/20 0.34
▸ MAPK1 P28482 2/20 0.34
▸ RAB9A P51151 2/20 0.34
▸ HTR3A P46098 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ CA1 P00915 2/20 0.33
▸ CA2 P00918 2/20 0.33
▸ CA9 Q16790 2/20 0.33
▸ PLA2G1B P04054 1/20 0.33
▸ ATG4B Q9Y4P1 1/20 0.33
▸ CTSB P07858 1/20 0.32
▸ CTSS P25774 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18220178 0.93 APP (0.46) APPRXFP1ALDH1A1MAPTKMT2A
SCHEMBL18220191 0.92 APP (0.47) APPALDH1A1MAPTKMT2AMEN1
SCHEMBL25610090 0.87 APP (0.46) APPRXFP1ALDH1A1MAPTKMT2A
SCHEMBL24068142 0.85 APP (0.41) APPRXFP1ALDH1A1MAPTKMT2A
SCHEMBL18220188 0.85 APP (0.51) APPRXFP1ALDH1A1MAPTATM
SCHEMBL18221501 0.85 APP (0.36) APPALDH1A1MAPTPRKD1KMT2A
SCHEMBL18220215 0.85 APP (0.36) APPALDH1A1MAPTPRKD1KMT2A
SCHEMBL18219866 0.84 APP (0.62) APPRXFP1ALDH1A1MAPTATM
SCHEMBL23134974 0.84 APP (0.41) APPALDH1A1MAPTKMT2AMEN1
SCHEMBL18220153 0.84 APP (0.47) APPRXFP1ALDH1A1MAPTPRKD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240208916-A1 AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME Amydis, Inc. 2024-06-27 — — US disclosed
US-11718596-B2 Amyloid targeting agents and methods of using the same THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-08-08 — — US disclosed
US-10005745-B2 Amyloid targeting agents and methods of using the same THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-06-26 — — US disclosed
US-20170248616-A1 IN VITRO COMPOSITIONS COMPRISING HUMAN SAMPLE AND AMYLOID TARGETING AGENT Amydis, Inc. 2017-08-31 — — US disclosed
US-20160326126-A1 AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME Amydis, Inc. 2016-11-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11718596-B2 Amyloid targeting agents and methods of using the same APP, CRYAA, APBA1 APP 1/4885RXFP1 4279/4885ALDH1A1 4151/4885
US-20240208916-A1 AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME APP, CRYAA, APBA1 APP 1/4885RXFP1 4279/4885ALDH1A1 4151/4885
US-20160326126-A1 AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME APP, APBA1, CRYAA APP 1/4885RXFP1 4325/4885ALDH1A1 4226/4885
US-10005745-B2 Amyloid targeting agents and methods of using the same APP, APBA1, CRYAA APP 1/4885RXFP1 4325/4885ALDH1A1 4226/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.