CRYAA — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL19181546	1.00	1/20
SCHEMBL19181547	1.00	1/20
SCHEMBL19194245	1.00	1/20
SCHEMBL19194136	0.87	1/20
SCHEMBL19198474	0.80	1/20
SCHEMBL288306	0.80	1/20
SCHEMBL288307	0.80	1/20
SCHEMBL568417	0.80	1/20
SCHEMBL6130528	0.80	1/20
SCHEMBL7527661	0.80	1/20
SCHEMBL13499192	0.80	1/20
SCHEMBL19198688	0.80	1/20
SCHEMBL26237645	0.80	1/20
SCHEMBL22759962	0.79	1/20
SCHEMBL22760016	0.79	1/20
SCHEMBL17431762	0.77	1/20
SCHEMBL620303	0.77	1/20
SCHEMBL19199340	0.77	1/20
SCHEMBL6130556	0.76	1/20
SCHEMBL19182359	0.76	1/20

Clinical trials — most relevant to CRYAA by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Comprehensive Study on Dry Eye and Ocular Surface Disease Prior and After Cataract Surgery	PHASE3	UNKNOWN
Management of Retinitis Pigmentosa Via Combination of Wharton's Jelly-derived Mesenchymal Stem Cells and Magnovision	PHASE3	COMPLETED
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors	PHASE1	COMPLETED
Cataract Surgery to Obtain Human Lens Material for the Study of Nuclear Cataracts	nan	COMPLETED
Studies of Families With Hereditary Cataracts	nan	COMPLETED
Proteomic Study of Tears From Patients With a PAX6 Mutation	nan	COMPLETED
Clinical and Genetic Studies of Families With Congenital or Hereditary Cataracts	nan	COMPLETED
PMCF Retrospective Study Outcomes of a Monofocal Toric Intraocular Lens	nan	COMPLETED
Genetic Diagnosis in Congenital Cataracts	nan	COMPLETED
Vitreous Proteomics of Patients Suffering From Pseudoexfoliation Syndrome	nan	ACTIVE_NOT_RECRUITING
Mechanism of Aphakic and Pseudophakic Glaucoma in Pediatric Patients	nan	COMPLETED
Gyrate Atrophy of the Choroid and Retina	nan	COMPLETED
Shanghai High Myopia Study	nan	RECRUITING
The Molecular Pathogenesis Study of Cataract	nan	UNKNOWN
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science	nan	RECRUITING
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma	nan	RECRUITING
Heart Aging When Near Vision Difficulty Begins	nan	COMPLETED
Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F	nan	ACTIVE_NOT_RECRUITING
Corneal Endothelium in Diabetics Undergoing Phacoemulsification	nan	UNKNOWN
Congenital Aniridia Patient Questionnaire	nan	RECRUITING
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models	nan	COMPLETED
Genetic Study of Age-Related Macular Degeneration	nan	COMPLETED
Whole Exome and Whole Genome Sequencing for Genotyping of Inherited and Congenital Eye Conditions	nan	RECRUITING
Telomerase Activator and Retinal Amyloid	nan	COMPLETED
Registry of Unexplained Cardiac Arrest	nan	COMPLETED
Monitoring of Early Disease Progression in Hereditary Transthyretin Amyloidosis	nan	COMPLETED
Clinical, Cellular, and Molecular Investigation Into Oculocutaneous Albinism	nan	COMPLETED
Ocular Bandage Gel (OBG) Pivotal Trial in Patients Undergoing Photorefractive Keratectomy (PRK)	nan	COMPLETED
Dynamic Light Scattering to Study Crystalline Proteins in Young Normal Lenses	nan	COMPLETED
The Pathogenesis of Human Senile Cataract	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CRYAA binder may also engage these)

Protein	Name	Similarity
P02488	—	1.000	P02488 →
P02498	—	1.000	P02498 →
P02494	—	1.000	P02494 →
P02470	—	1.000	P02470 →
P68285	—	1.000	P68285 →
P02482	—	1.000	P02482 →
P02486	—	1.000	P02486 →
P02499	—	1.000	P02499 →
P02504	—	1.000	P02504 →
P68281	—	1.000	P68281 →
P02479	—	1.000	P02479 →
P82531	—	1.000	P82531 →
P02506	—	1.000	P02506 →
P02478	—	0.999	P02478 →
P02480	—	0.999	P02480 →
P02502	—	0.999	P02502 →
P02484	—	0.998	P02484 →
P02476	—	0.998	P02476 →
P02474	—	0.998	P02474 →
P02487	—	0.998	P02487 →
P68288	—	0.997	P68288 →
Q5ENZ0	—	0.997	Q5ENZ0 →
P02475	—	0.997	P02475 →
P68283	—	0.997	P68283 →
P02505	—	0.997	P02505 →
P68405	—	0.997	P68405 →
P68284	—	0.997	P68284 →
P02477	—	0.997	P02477 →
P02483	—	0.997	P02483 →
P02501	—	0.996	P02501 →