Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 15/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15559787 | 0.85 | ELANE (0.52) | ELANELRRK2KDM4DTLR8IMPDH2 | |
| SCHEMBL7844045 | 0.84 | ELANE (0.57) | ELANELRRK2KDM4DCDK2IMPDH2 | |
| SCHEMBL15559790 | 0.78 | ELANE (0.48) | ELANELRRK2KDM4DTLR8IMPDH2 | |
| SCHEMBL28914834 | 0.76 | ELANE (0.55) | ELANELRRK2KDM4DCDK2IMPDH2 | |
| SCHEMBL12146949 | 0.76 | ELANE (0.57) | ELANELRRK2KDM4DCDK2IMPDH2 | |
| SCHEMBL20674541 | 0.76 | ELANE (0.61) | ELANELRRK2KDM4DCDK2 | |
| SCHEMBL28049881 | 0.76 | ELANE (0.57) | ELANELRRK2KDM4DCDK2IMPDH2 | |
| SCHEMBL16464569 | 0.76 | ELANE (0.61) | ELANELRRK2KDM4DCDK2IMPDH2 | |
| SCHEMBL28822922 | 0.76 | ELANE (0.57) | ELANELRRK2KDM4DCDK2IMPDH2 | |
| SCHEMBL18188566 | 0.75 | KMT2A (0.43) | ELANEIMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501236-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | Plexxikon, Inc. (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011063159-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2011-05-26 | — | — | WO | disclosed |