Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 20/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1614900 | 1.00 | MAP3K14 (0.64) | MAP3K14MAP4K4JAK1JAK3TNK2 | |
| SCHEMBL1614897 | 1.00 | MAP3K14 (0.64) | MAP3K14MAP4K4JAK1JAK3TNK2 | |
| SCHEMBL1612839 | 0.96 | MAP3K14 (0.69) | MAP3K14MAP4K4JAK1JAK3TNK2 | |
| SCHEMBL1612312 | 0.87 | MAP3K14 (0.59) | MAP3K14MAP4K4 | |
| SCHEMBL1612311 | 0.87 | MAP3K14 (0.59) | MAP3K14MAP4K4 | |
| SCHEMBL12743907 | 0.86 | MAP3K14 (0.46) | MAP3K14MAP4K4 | |
| SCHEMBL12743544 | 0.86 | MAP3K14 (0.46) | MAP3K14MAP4K4 | |
| SCHEMBL1613689 | 0.85 | MAP3K14 (0.72) | MAP3K14JAK1JAK3TNK2NTRK3 | |
| SCHEMBL1822048 | 0.84 | MAP3K14 (0.45) | MAP3K14 | |
| SCHEMBL1822045 | 0.84 | MAP3K14 (0.45) | MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315751-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | Amgen Inc. (US) | 2011-05-04 | — | — | EP | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |