Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.43 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.43 |
| ▸ | ITGAL | P20701 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | CRHBP | P24387 | 2/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182198 | 0.88 | ITGB2 (0.33) | ITGB2ICAM1ITGALSMN1; SMN2HPGD | |
| SCHEMBL17626547 | 0.69 | NPC1 (0.42) | SMN1; SMN2LMNAHTTMAPTKDM4E | |
| SCHEMBL17646200 | 0.69 | NPC1 (0.42) | SMN1; SMN2LMNAHTTMAPTKDM4E | |
| SCHEMBL17646207 | 0.69 | NPC1 (0.42) | SMN1; SMN2LMNAHTTMAPTKDM4E | |
| SCHEMBL13236592 | 0.66 | CYP3A4 (0.41) | HTTHPGDGAAMAPTKDM4E | |
| SCHEMBL27382541 | 0.65 | ITGB2 (0.53) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL182137 | 0.65 | — | — | |
| SCHEMBL7266796 | 0.63 | — | — | |
| SCHEMBL6365029 | 0.63 | ITGB2 (0.38) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL8525889 | 0.62 | ALDH1A1 (0.47) | ITGB2ICAM1ITGALSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979916-B1 | CHEMICAL DEFUNCTIONALIZATION OF POLYMERIC ALKYLENEDIOXYHETEROCYCLICS | UNIV FLORIDA (US) | 2012-03-21 | — | — | EP | claimed |
| US-7807758-B2 | Chemical defunctionalization of polymeric alkylenedioxyheterocyclics | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-10-05 | — | — | US | claimed |
| US-20090221763-A1 | Chemical Defunctionalization of Polymeric Alkylenedioxyheterocyclics | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-09-03 | — | — | US | claimed |
| EP-1979916-A2 | CHEMICAL DEFUNCTIONALIZATION OF POLYMERIC ALKYLENEDIOXYHETEROCYCLICS | University of Florida Research Foundation, Incorporated (US) | 2008-10-15 | — | — | EP | claimed |
| US-20070202612-A1 | Plasma-Polymerisation Of Polycylic Compounds | FORSKININGSCENTER RISO | 2007-08-30 | — | — | US | claimed |
| WO-2007087587-A2 | CHEMICAL DEFUNCTIONALIZATION OF POLYMERIC ALKYLENEDIOXYHETEROCYCLICS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2007-08-02 | — | — | WO | claimed |
| WO-2005092521-A2 | PLASMA-POLYMERISATION OF POLYCYCLIC COMPOUNDS | Forskningscenter Risø (DK) | 2005-10-06 | — | — | WO | claimed |
| EP-2402955-B1 | Chemical defunctionalization of polymeric alkylenedioxyheterocyclics - the monomers | UNIV FLORIDA (US) | 2013-07-03 | — | — | EP | disclosed |
| EP-1979916-B1 | CHEMICAL DEFUNCTIONALIZATION OF POLYMERIC ALKYLENEDIOXYHETEROCYCLICS | UNIV FLORIDA (US) | 2012-03-21 | — | — | EP | disclosed |
| EP-2402955-A1 | Chemical defunctionalization of polymeric alkylenedioxyheterocyclics - the monomers | University of Florida Research Foundation, Incorporated (US) | 2012-01-04 | — | — | EP | disclosed |
| US-7807758-B2 | Chemical defunctionalization of polymeric alkylenedioxyheterocyclics | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-10-05 | — | — | US | disclosed |
| US-20090221763-A1 | Chemical Defunctionalization of Polymeric Alkylenedioxyheterocyclics | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-09-03 | — | — | US | disclosed |
| EP-1979916-A2 | CHEMICAL DEFUNCTIONALIZATION OF POLYMERIC ALKYLENEDIOXYHETEROCYCLICS | University of Florida Research Foundation, Incorporated (US) | 2008-10-15 | — | — | EP | disclosed |
| US-20070202612-A1 | Plasma-Polymerisation Of Polycylic Compounds | FORSKININGSCENTER RISO | 2007-08-30 | — | — | US | disclosed |
| US-20070202612-A1 | Plasma-Polymerisation Of Polycylic Compounds | FORSKININGSCENTER RISO | 2007-08-30 | — | — | US | disclosed |
| WO-2007087587-A2 | CHEMICAL DEFUNCTIONALIZATION OF POLYMERIC ALKYLENEDIOXYHETEROCYCLICS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2007-08-02 | — | — | WO | disclosed |
| WO-2005092521-A3 | PLASMA-POLYMERISATION OF POLYCYCLIC COMPOUNDS | FORSKNINGSCT RISOE (DK) | 2006-03-02 | — | — | WO | disclosed |
| WO-2005092521-A2 | PLASMA-POLYMERISATION OF POLYCYCLIC COMPOUNDS | Forskningscenter Risø (DK) | 2005-10-06 | — | — | WO | disclosed |
| WO-2005092521-A2 | PLASMA-POLYMERISATION OF POLYCYCLIC COMPOUNDS | Forskningscenter Risø (DK) | 2005-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221763-A1 | Chemical Defunctionalization of Polymeric Alkylenedioxyheterocyclics | DDT, STAT3, PTPN22 | ITGB2 2691/4885ICAM1 4479/4885ITGAL 3030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.