Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL604932 | 0.80 | HRH4 (1.00) | HRH4HRH3POLBSMN1; SMN2 | |
| SCHEMBL6153659 | 0.79 | HRH4 (0.76) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL26490547 | 0.78 | HRH4 (0.70) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL604296 | 0.78 | HRH4 (1.00) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL7710603 | 0.76 | AKR1C3 (0.69) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL2350768 | 0.76 | HRH4 (0.78) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL4457694 | 0.76 | HRH4 (0.70) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL4477180 | 0.76 | HRH4 (0.70) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL4327043 | 0.76 | HRH4 (0.63) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL8984734 | 0.76 | HRH4 (0.71) | HRH4HRH3AKR1C3POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315521-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H 4 RECEPTOR | Janssen Pharmaceutica NV (BE) | 2011-05-04 | — | — | EP | disclosed |
| WO-2009152325-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-17 | — | — | WO | disclosed |
| WO-2004108671-A1 | SUBSTITUTED INDOLES WITH SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SUVEN LIFE SCIENCES LIMITED (IN) | 2004-12-16 | — | — | WO | disclosed |