Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.76 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.66 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | RBP4 | P02753 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL604296 | 0.86 | HRH4 (1.00) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL3260438 | 0.85 | HRH4 (0.76) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL2679610 | 0.80 | HRH4 (1.00) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL29699763 | 0.80 | HRH4 (1.00) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL1822962 | 0.79 | HRH4 (0.67) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL7710603 | 0.77 | AKR1C3 (0.69) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL2350768 | 0.77 | HRH4 (0.78) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL29743974 | 0.76 | AKR1C3 (0.67) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL20267078 | 0.76 | AKR1C3 (0.67) | HRH4HRH3AKR1C3POLBSMN1; SMN2 | |
| SCHEMBL26490547 | 0.76 | HRH4 (0.70) | HRH4HRH3AKR1C3POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551406-A1 | USE OF INDOLYL DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF ALLERGIC RHINITIS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004022061-A1 | USE OF INDOLYL DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT ALLERGIC RHINITIS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-03-18 | — | — | WO | disclosed |