Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 18/20 | 1.00 |
| ▸ | CCNH | P51946 | 17/20 | 1.00 |
| ▸ | CDK5 | Q00535 | 4/20 | 1.00 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 1.00 |
| ▸ | CDK1 | P06493 | 2/20 | 1.00 |
| ▸ | CDK2 | P24941 | 2/20 | 1.00 |
| ▸ | CDK9 | P50750 | 2/20 | 1.00 |
| ▸ | MNAT1 | P51948 | 2/20 | 1.00 |
| ▸ | CDK13 | Q14004 | 2/20 | 1.00 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 1.00 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 1.00 |
| ▸ | CCNT1 | O60563 | 1/20 | 1.00 |
| ▸ | CCNK | O75909 | 1/20 | 1.00 |
| ▸ | CCNB1 | P14635 | 1/20 | 1.00 |
| ▸ | CCNA2 | P20248 | 1/20 | 1.00 |
| ▸ | MAPK8 | P45983 | 1/20 | 1.00 |
| ▸ | MAPK9 | P45984 | 1/20 | 1.00 |
| ▸ | CDK8 | P49336 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14979765 | 1.00 | CDK7 (1.00) | CDK7CCNHCDK5CDK5R1CDK1 | |
| SCHEMBL29434968 | 1.00 | CDK7 (1.00) | CDK7CCNHCDK5CDK5R1CDK1 | |
| SCHEMBL23682983 | 1.00 | CDK7 (1.00) | CDK7CCNHCDK5CDK5R1CDK1 | |
| SCHEMBL29355500 | 1.00 | CDK7 (1.00) | CDK7CCNHCDK5CDK5R1CDK1 | |
| Hydrochloric Acid SCHEMBL29867414 | 0.99 | CDK7 (0.99) | CDK7CCNHCDK5CDK5R1CDK1 | |
| SCHEMBL18313531 | 0.95 | CDK7 (0.94) | CDK7CCNHCDK5CDK5R1CDK1 | |
| SCHEMBL30337868 | 0.95 | CDK7 (1.00) | CDK7CCNHCDK5CDK5R1CDK1 | |
| SCHEMBL18313553 | 0.95 | CDK7 (1.00) | CDK7CCNHCDK5CDK5R1CDK1 | |
| SCHEMBL29355486 | 0.95 | CDK7 (1.00) | CDK7CCNHCDK5CDK5R1CDK1 | |
| SCHEMBL18313499 | 0.95 | CDK7 (1.00) | CDK7CCNHCDK5CDK5R1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112716957-A | Application of CDK7 targeted inhibitor in preparation of medicine for treating cytokine release syndrome caused by CAR-T treatment | 复旦大学附属肿瘤医院 | 2021-04-30 | — | — | CN | disclosed |
| CN-112656798-A | Application of CDK7 targeted inhibitor in preparation of drug for treating cytokine release syndrome | 复旦大学附属肿瘤医院 | 2021-04-16 | — | — | CN | disclosed |
| CN-112076194-A | Application of compound for targeted inhibition of CDK7 in preparation of compounds for inhibiting triple negative breast cancer stem cells | 复旦大学附属肿瘤医院 | 2020-12-15 | — | — | CN | disclosed |
| US-20200123499-A1 | METHOD FOR EFFICIENT GENERATION OF NEURONS FROM NON-NEURONAL CELLS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2020-04-23 | — | — | US | disclosed |
| EP-3416970-A1 | CORTISTATIN ANALOGS | President and Fellows of Harvard College (US) | 2018-12-26 | — | — | EP | disclosed |
| EP-3394038-A1 | TARGETED SELECTION OF PATIENTS FOR TREATMENT WITH SPECIFIC CORTISTATIN DERIVATIVES | President and Fellows of Harvard College (US) | 2018-10-31 | — | — | EP | disclosed |
| EP-3394072-A1 | CORTISTATIN ANALOGS AND USES THEREOF | President and Fellows of Harvard College (US) | 2018-10-31 | — | — | EP | disclosed |
| EP-3294418-A1 | TARGETED SELECTION OF PATIENTS FOR TREATMENT WITH CORTISTATIN DERIVATIVES | President and Fellows of Harvard College (US) | 2018-03-21 | — | — | EP | disclosed |
| WO-2017142621-A1 | CORTISTATIN ANALOGS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-08-24 | — | — | WO | disclosed |
| WO-2017112815-A1 | CORTISTATIN ANALOGS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-06-29 | — | — | WO | disclosed |
| WO-2017112823-A1 | TARGETED SELECTION OF PATIENTS FOR TREATMENT WITH SPECIFIC CORTISTATIN DERIVATIVES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-06-29 | — | — | WO | disclosed |
| WO-2016182904-A1 | TARGETED SELECTION OF PATIENTS FOR TREATMENT WITH CORTISTATIN DERIVATIVES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-17 | — | — | WO | disclosed |