SCHEMBL29355486

SCHEMBL29355486

CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2cccc(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)c2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CDK7 P50613 17/20 1.00
CCNH P51946 16/20 1.00
CDK5 Q00535 4/20 1.00
CDK1 P06493 2/20 1.00
CDK2 P24941 2/20 1.00
CDK9 P50750 2/20 1.00
MNAT1 P51948 2/20 1.00
CDK8 P49336 1/20 1.00
CDK5R1 Q15078 3/20 0.91
MAP3K11 Q16584 2/20 0.91
CDK13 Q14004 2/20 0.91
CDK12 Q9NYV4 2/20 0.91
CCNT1 O60563 1/20 0.91
CCNK O75909 1/20 0.91
CCNB1 P14635 1/20 0.91
CCNA2 P20248 1/20 0.91
MAPK8 P45983 1/20 0.91
MAPK9 P45984 1/20 0.91
EGFR P00533 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18313553 1.00 CDK7 (1.00) CDK7CCNHCDK5CDK1CDK2
SCHEMBL30337868 1.00 CDK7 (1.00) CDK7CCNHCDK5CDK1CDK2
SCHEMBL18313531 0.97 CDK7 (0.94) CDK7CCNHCDK5CDK1CDK2
SCHEMBL14979756 0.96 CDK7 (0.93) CDK7CCNHCDK5CDK1CDK2
SCHEMBL23682983 0.95 CDK7 (1.00) CDK7CCNHCDK5CDK1CDK2
SCHEMBL14979765 0.95 CDK7 (1.00) CDK7CCNHCDK5CDK1CDK2
SCHEMBL29434968 0.95 CDK7 (1.00) CDK7CCNHCDK5CDK1CDK2
SCHEMBL18229934 0.95 CDK7 (1.00) CDK7CCNHCDK5CDK1CDK2
SCHEMBL29355500 0.95 CDK7 (1.00) CDK7CCNHCDK5CDK1CDK2
SCHEMBL18078676 0.95 CDK7 (0.90) CDK7CCNHCDK5CDK1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 146 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4712346-A1 COMPOSITE SUBSTRATE FOR SURFACE ACOUSTIC WAVE DEVICES SHIN-ETSU CHEMICAL CO., LTD. (JP) 2026-03-18 EP claimed
EP-4695235-A1 NOVEL GSPT1 DEGRADER AND USE THEREOF Cyrus Therapeutics Inc. (KR) 2026-02-18 EP claimed
EP-4529926-A1 METHOD FOR TREATING CANCER BY COMBINING ALKYLATING AGENT PRODRUG AND CELL CYCLE INHIBITOR Ascentawits Pharmaceuticals, Ltd. (CN) 2025-04-02 EP claimed
CN-119233822-A Methods of treating cancer using alkylating agent prodrugs and cell cycle inhibitors in combination 深圳艾欣达伟医药科技有限公司 2024-12-31 CN claimed
WO-2024232192-A1 COMPOSITE SUBSTRATE FOR SURFACE ACOUSTIC WAVE DEVICES 信越化学工業株式会社 2024-11-14 WO claimed
CN-118938466-A Super-surface cascading system for terahertz phase contrast imaging and design method thereof 北京理工大学 2024-11-12 CN claimed
US-12135282-B2 Method of imaging a sample material THE UNIVERSITY OF WESTERN AUSTRALIA (AU) 2024-11-05 US claimed
WO-2024215130-A1 NOVEL GSPT1 DEGRADER AND USE THEREOF CYRUS THERAPEUTICS INC. (KR) 2024-10-17 WO claimed
CN-115078300-B High-resolution terahertz characteristic spectral line precision test device and test method 中电科思仪科技股份有限公司 2024-07-26 CN claimed
CN-117291094-B Unmanned aerial vehicle power system parameter anomaly detection method based on associated parameter mapping 成都飞机工业(集团)有限责任公司 2024-07-12 CN claimed
WO-2024073399-A2 DNA-AFFIBODY-DRUG NANOSTRUCTURES FOR INHIBITING TRIPLE NEGATIVE BREAST CANCER GROWTH AND METASTASIS ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2024-04-04 WO claimed
WO-2023226959-A1 METHOD FOR TREATING CANCER BY COMBINING ALKYLATING AGENT PRODRUG AND CELL CYCLE INHIBITOR 深圳艾欣达伟医药科技有限公司 2023-11-30 WO claimed
CN-116612639-A Terahertz-based pedestrian crossing application recognition control method 维特瑞交通科技有限公司 2023-08-18 CN claimed
US-20230210852-A1 METHODS OF TREATING CANCER IN PATIENTS WITH AN ANOMALOUS KRAS GENE OR DELETIONS WITHIN CHROMOSOME 9 MEDIC LIFE SCIENCES, INC. 2023-07-06 US claimed
EP-4157465-A2 METHODS OF TREATING CANCER IN PATIENTS WITH AN ANOMALOUS KRAS GENE OR DELETIONS WITHIN CHROMOSOME 9 Syros Pharmaceuticals, Inc. (US) 2023-04-05 EP claimed
CN-112670792-B Device for simultaneously generating multi-frequency terahertz waves based on optimized cascade difference frequency 华北水利水电大学 2023-03-24 CN claimed
US-20220305003-A1 METHODS OF TREATING CANCER WITH AN INHIBITOR OF ZNF827 CHILDREN'S MEDICAL RESEARCH INSTITUTE (AU) 2022-09-29 US claimed
CN-115078300-A High-resolution terahertz characteristic spectral line precision testing device and testing method 中电科思仪科技股份有限公司 2022-09-20 CN claimed
US-20220276161-A1 A METHOD OF IMAGING A SAMPLE MATERIAL THE UNIVERSITY OF WESTERN AUSTRALIA (AU) 2022-09-01 US claimed
EP-3982977-A1 METHODS OF TREATING CANCER WITH AN INHIBITOR OF ZNF827 Children's Medical Research Institute (AU) 2022-04-20 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230210852-A1 METHODS OF TREATING CANCER IN PATIENTS WITH AN ANOMALOUS KRAS GENE OR DELETIONS WITHIN CHROMOSOME 9 CDKL5, KRAS, CDK9 CDK7 12/4885CCNH 255/4885CDK5 71/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.