SCHEMBL1823484

SCHEMBL1823484

O=C(O)CCc1ccc(N2C(=O)C=CC2=O)cc1

nearest known ligand 0.62

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 1/20 0.62
PPARA Q07869 1/20 0.62
MGLL Q99685 9/20 0.61
FAAH O00519 5/20 0.58
DDAH1 O94760 1/20 0.55
FFAR1 O14842 4/20 0.53
KEAP1 Q14145 1/20 0.52
HSP90AA1 P07900 1/20 0.50
PKM P14618 1/20 0.50
MAPK1 P28482 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
ITGB3 P05106 1/20 0.47
ITGA2B P08514 1/20 0.47
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
FFAR4 Q5NUL3 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL514697 0.90 MGLL (0.59) PPARDPPARAMGLLFAAHDDAH1
Hydrochloric Acid SCHEMBL28737900 0.88 MGLL (0.58) PPARDPPARAMGLLFAAHDDAH1
Hydrazine SCHEMBL27822007 0.87 MGLL (0.56) PPARDPPARAMGLLFAAHDDAH1
SCHEMBL4388793 0.82 MGLL (0.77) MGLLFAAHDDAH1HSP90AA1PKM
SCHEMBL6755043 0.81 MGLL (0.62) MGLLFAAHDDAH1HSP90AA1PKM
Hydrochloric Acid SCHEMBL6753371 0.80 MGLL (0.60) MGLLFAAHDDAH1HSP90AA1PKM
SCHEMBL8510655 0.80 MGLL (0.49) PPARDPPARAMGLLFAAHDDAH1
Succinimide SCHEMBL132748 0.80 MGLL (0.49) PPARDPPARAMGLLFAAHDDAH1
SCHEMBL9751413 0.79 MGLL (0.67) MGLLFAAHDDAH1HSP90AA1PKM
SCHEMBL741572 0.79 MGLL (0.59) PPARDPPARAMGLLFAAHDDAH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4373824-A1 IMMUNOCONJUGATES AND METHODS Zeno Management, Inc. (US) 2024-05-29 EP disclosed
CN-117715913-A Immunoconjugates and methods 芝诺管理公司 2024-03-15 CN disclosed
US-11806405-B1 Immunoconjugates and methods ZENO MANAGEMENT, INC. (US) 2023-11-07 US disclosed
WO-2023004266-A1 IMMUNOCONJUGATES AND METHODS RECURIUM IP HOLDINGS, LLC (US) 2023-01-26 WO disclosed
EP-2256133-B1 Bioconjugation of macromolecules SIGMA ALDRICH CO LLC (US) 2016-12-14 EP disclosed
EP-2319854-B1 Bioconjugation Of Macromolecules SIGMA ALDRICH CO LLC (US) 2016-11-30 EP disclosed
US-9045552-B2 Non-viral delivery of compounds to mitochondria WAKE FOREST UNIVERSITY (US) 2015-06-02 US disclosed
US-8735341-B2 Non-viral delivery of compounds to mitochondria WAKE FOREST UNIVERSITY (US) 2014-05-27 US disclosed
US-8283444-B2 biodrug fusion protein comprising active mitochondrial protein or peptide, a mitochondrial membrane-permeant peptide and linking to a mitochondrial targeting sequence; targeting sequence is cleaved within the mitochondrial matrix, and not cleaved within the cellular cytoplasm; mitochondrial disorders WAKE FOREST UNIVERSITY (US) 2012-10-09 US disclosed
US-20110245146-A1 Non-Viral Delivery of Compounds to Mitochondria PAYNE R MARK 2011-10-06 US disclosed
US-20050169904-A1 Non-viral delivery of compounds to mitochondria WAKE FOREST UNIVERSITY 2005-08-04 US disclosed
WO-2005042560-A2 NON-VIRAL DELIVERY OF COMPOUNDS TO MITOCHONDRIA WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) 2005-05-12 WO disclosed
US-6737236-B1 DERIVATIZING OLIGONUCLEOTIDES AND PROTEINS USING CYCLOADDITION REACTIONS INCLUDING DIELS-ALDER REACTION OR 1,3-DIPOLAR CYCLOADDITION REACTIONS PROLIGO, LLC 2004-05-18 US disclosed
US-20030215801-A1 Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method SIGMA-ALDRICH CO., LLC 2003-11-20 US disclosed
EP-1287404-A4 METHOD FOR IMMOBILIZING OLIGONUCLEOTIDES EMPLOYING THE CYCLOADDITION BIOCONJUGATION METHOD PROLIGO LLC (US) 2003-10-15 EP disclosed
EP-1287404-A1 METHOD FOR IMMOBILIZING OLIGONUCLEOTIDES EMPLOYING THE CYCLOADDITION BIOCONJUGATION METHOD Proligo LLC (US) 2003-03-05 EP disclosed
WO-2001084234-A1 METHOD FOR IMMOBILIZING OLIGONUCLEOTIDES EMPLOYING THE CYCLOADDITION BIOCONJUGATION METHOD PROLIGO LLC (US) 2001-11-08 WO disclosed
EP-0968223-A1 BIOCONJUGATION OF MACROMOLECULES Proligo L.L.C. (US) 2000-01-05 EP disclosed
WO-1998030575-A1 BIOCONJUGATION OF MACROMOLECULES PROLIGO LLC (US) 1998-07-16 WO disclosed
EP-0001997-B1 ELECTRON BEAM-CURABLE PHOTORESIST LACQUERS BAYER AG (DE) 1981-02-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11806405-B1 Immunoconjugates and methods CD4, L1CAM, PDCD1LG2 PPARD 3528/4885PPARA 3771/4885MGLL 1892/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.