Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | NLN | Q9BYT8 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1825415 | 0.89 | TP53 (0.48) | TP53MAPTPOLBMEN1KMT2A | |
| SCHEMBL1826299 | 0.88 | TP53 (0.42) | EGFRSRCTP53MAPTPOLB | |
| SCHEMBL1825821 | 0.88 | MMP2 (0.41) | EGFRSRCTP53MAPTPOLB | |
| SCHEMBL1615347 | 0.86 | TP53 (0.49) | EGFRSRCTP53MAPTPOLB | |
| SCHEMBL1826130 | 0.85 | TP53 (0.44) | TP53MAPTPOLBMEN1KMT2A | |
| SCHEMBL1825496 | 0.85 | TP53 (0.45) | TP53MAPTPOLBMEN1KMT2A | |
| SCHEMBL1826407 | 0.85 | TP53 (0.46) | TP53MAPTPOLBMEN1KMT2A | |
| SCHEMBL1826315 | 0.81 | TP53 (0.42) | TP53MAPTPOLBMEN1KMT2A | |
| SCHEMBL1823406 | 0.80 | POLB (0.42) | TP53MAPTPOLBMEN1KMT2A | |
| SCHEMBL1824783 | 0.80 | MAPT (0.44) | TP53MAPTPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794122-B1 | 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I | AVENTIS PHARMA INC (US) | 2011-05-04 | — | — | EP | claimed |