Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 7/20 | 0.47 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.43 |
| ▸ | SGK1 | O00141 | 3/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16945259 | 1.00 | AXL (0.47) | AXLMAP3K11SGK1CAMKK2AAK1 | |
| SCHEMBL18250581 | 0.90 | AXL (0.47) | AXLMAP3K11SGK1CAMKK2AAK1 | |
| SCHEMBL18238835 | 0.89 | AXL (0.45) | AXLMAP3K11SGK1CAMKK2AAK1 | |
| SCHEMBL16949395 | 0.89 | AXL (0.45) | AXLMAP3K11SGK1CAMKK2AAK1 | |
| SCHEMBL18238242 | 0.89 | AXL (0.53) | AXLMAP3K11SGK1CAMKK2AAK1 | |
| SCHEMBL16949043 | 0.89 | AXL (0.53) | AXLMAP3K11SGK1CAMKK2AAK1 | |
| SCHEMBL18250466 | 0.88 | AAK1 (0.47) | AXLMAP3K11SGK1CAMKK2AAK1 | |
| SCHEMBL18238580 | 0.88 | MAP3K11 (0.44) | AXLMAP3K11SGK1CAMKK2AAK1 | |
| SCHEMBL16949119 | 0.88 | MAP3K11 (0.44) | AXLMAP3K11SGK1CAMKK2AAK1 | |
| SCHEMBL16949397 | 0.87 | BRD4 (0.50) | AXLMAP3K11SGK1CAMKK2AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499551-B2 | Substituted pyrrolo[2,3-b]pyridines for treating cancer or inflammatory diseases | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-11-22 | — | — | US | disclosed |