Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 8/20 | 0.54 |
| ▸ | TAB1 | Q15750 | 8/20 | 0.54 |
| ▸ | SGK1 | O00141 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16945169 | 1.00 | MAP3K7 (0.54) | MAP3K7TAB1SGK1KITAXL | |
| SCHEMBL18250493 | 0.91 | MAP3K7 (0.43) | MAP3K7TAB1SGK1KITAXL | |
| SCHEMBL18238117 | 0.89 | MAP3K7 (0.53) | MAP3K7TAB1SGK1AXLCLK1 | |
| SCHEMBL16945198 | 0.89 | MAP3K7 (0.53) | MAP3K7TAB1SGK1AXLCLK1 | |
| SCHEMBL16948727 | 0.88 | MAP3K7 (0.60) | MAP3K7TAB1 | |
| SCHEMBL18238764 | 0.88 | MAP3K7 (0.60) | MAP3K7TAB1 | |
| SCHEMBL16932982 | 0.86 | KIT (0.55) | MAP3K7TAB1SGK1KITAXL | |
| SCHEMBL16932979 | 0.86 | KIT (0.55) | MAP3K7TAB1SGK1KITAXL | |
| SCHEMBL16945176 | 0.85 | SGK1 (0.48) | MAP3K7TAB1SGK1AXLCLK1 | |
| SCHEMBL18239033 | 0.85 | SGK1 (0.48) | MAP3K7TAB1SGK1AXLCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499551-B2 | Substituted pyrrolo[2,3-b]pyridines for treating cancer or inflammatory diseases | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-11-22 | — | — | US | disclosed |