SCHEMBL18239885

SCHEMBL18239885

CC(C)(C)[Si](C)(C)O[C@@H](CNCc1ccc(CCCNC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)cc1)c1ccc(O)c2[nH]c(=O)ccc12

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 20/20 0.68
CHRM3 P20309 20/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL730048 0.94 CHRM3 (0.73) ADRB2CHRM3
SCHEMBL28171865 0.93 ADRB2 (0.69) ADRB2CHRM3
SCHEMBL18239946 0.93 ADRB2 (0.69) ADRB2CHRM3
SCHEMBL732159 0.93 CHRM3 (0.72) ADRB2CHRM3
SCHEMBL18239886 0.90 ADRB2 (0.84) ADRB2CHRM3
SCHEMBL730376 0.88 ADRB2 (0.70) ADRB2CHRM3
SCHEMBL730375 0.88 ADRB2 (0.70) ADRB2CHRM3
SCHEMBL699729 0.88 ADRB2 (0.70) ADRB2CHRM3
SCHEMBL730783 0.88 CHRM3 (0.75) ADRB2CHRM3
SCHEMBL731806 0.88 ADRB2 (0.71) ADRB2CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016180349-A1 BIPHENYL DERIVATIVE HAVING BETA2 RECEPTOR EXCITEMENT AND M RECEPTOR ANTAGONISTIC ACTIVITIES AND APPLICATION THEREFOF IN MEDICAMENT 四川海思科制药有限公司 2016-11-17 WO disclosed