Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | MC5R | P33032 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26213 | 0.73 | CYP1A2 (0.60) | CYP1A2CYP2A6HTR2AHTR2CHTR2B | |
| SCHEMBL27028324 | 0.72 | CYP1A2 (0.53) | CYP1A2CYP2A6HTR2AHTR2CHTR2B | |
| SCHEMBL292209 | 0.72 | CYP1A2 (0.41) | CYP1A2CYP2A6KMT2AFAAH | |
| Ethylene SCHEMBL27321489 | 0.70 | CYP2A6 (0.91) | CYP1A2CYP2A6HTR2AHTR2CHTR2B | |
| SCHEMBL128640 | 0.70 | CYP1A2 (0.56) | CYP1A2CYP2A6HTR2AHTR2CHTR2B | |
| SCHEMBL18270291 | 0.69 | CYP1A2 (0.55) | CYP1A2CYP2A6HTR2AHTR2CHTR2B | |
| SCHEMBL27028326 | 0.69 | CYP1A2 (0.55) | CYP1A2CYP2A6HTR2AHTR2CHTR2B | |
| SCHEMBL9974257 | 0.69 | CYP1A2 (0.60) | CYP1A2CYP2A6HTR2AHTR2CHTR2B | |
| SCHEMBL17386480 | 0.69 | CYP1A2 (0.60) | CYP1A2CYP2A6HTR2AHTR2CHTR2B | |
| SCHEMBL73386 | 0.69 | CYP2A6 (1.00) | CYP1A2CYP2A6HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10874740-B2 | 5-ALA derivatives and use thereof | UNIVERSITE DE GENEVE (CH) | 2020-12-29 | — | — | US | disclosed |
| EP-3297675-B1 | 5-ALA DERIVATIVES | UNIV GENEVE (CH) | 2020-07-08 | — | — | EP | disclosed |
| US-20190240329-A1 | 5-ALA DERIVATIVES AND USE THEREOF | UNIVERSITE DE GENEVE (CH) | 2019-08-08 | — | — | US | disclosed |
| US-10258690-B2 | 5-ALA derivatives and use thereof | UNIVERSITE DE GENEVE (CH) | 2019-04-16 | — | — | US | disclosed |
| US-20180133320-A1 | 5-ALA DERIVATIVES AND USE THEREOF | UNIVERSITE DE GENEVE (CH) | 2018-05-17 | — | — | US | disclosed |
| EP-3297675-A1 | 5-ALA DERIVATIVES AND USE THEREOF | Université de Genève (CH) | 2018-03-28 | — | — | EP | disclosed |
| WO-2016185368-A1 | 5-ALA DERIVATIVES AND USE THEREOF | UNIVERSITE DE GENEVE (CH) | 2016-11-24 | — | — | WO | disclosed |
| EP-3095464-A1 | 5-ALA DERIVATIVES AND USE THEREOF | UNIVERSITE DE GENEVE (CH) | 2016-11-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190240329-A1 | 5-ALA DERIVATIVES AND USE THEREOF | ALAD, ANXA5, AAAS | CYP1A2 561/4885CYP2A6 1047/4885HTR2A 1996/4885 |
| US-20180133320-A1 | 5-ALA DERIVATIVES AND USE THEREOF | ALAD, ANXA5, AAAS | CYP1A2 561/4885CYP2A6 1047/4885HTR2A 1996/4885 |
| US-10874740-B2 | 5-ALA derivatives and use thereof | ALAD, ANXA5, AAAS | CYP1A2 561/4885CYP2A6 1047/4885HTR2A 1996/4885 |
| US-10258690-B2 | 5-ALA derivatives and use thereof | ALAD, ANXA5, AAAS | CYP1A2 561/4885CYP2A6 1047/4885HTR2A 1996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.