ALAD — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2652069	1.00	2/20
SCHEMBL6142121	1.00	2/20
SCHEMBL3049093	0.72	2/20
SCHEMBL15177354	0.72	2/20
SCHEMBL24176394	0.72	2/20
SCHEMBL6450949	0.71	2/20
SCHEMBL6368361	0.71	2/20
SCHEMBL6704697	0.71	2/20
SCHEMBL505511	0.70	2/20
SCHEMBL1800477	0.69	2/20
SCHEMBL3625585	0.69	2/20
SCHEMBL6142253	0.69	2/20
SCHEMBL6143622	0.69	2/20
SCHEMBL6451881	0.68	2/20
SCHEMBL13246751	0.66	2/20
SCHEMBL13267656	0.66	2/20
SCHEMBL21563725	0.66	2/20
SCHEMBL27794744	0.66	2/20
SCHEMBL4381926	0.66	2/20
SCHEMBL6142371	0.65	2/20

Clinical trials — most relevant to ALAD by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Safety of Treatment of Actinic Keratoses With Photodynamic Therapy Between MAL Cream and ALA Gel	PHASE4	UNKNOWN
A Laser Detection for Bladder Cancer by (Photodynamic) Spectra of Urine	PHASE3	COMPLETED
Study of Bitopertin in Participants With EPP or XLP (APOLLO)	PHASE3	ACTIVE_NOT_RECRUITING
ENVISION: A Study to Evaluate the Efficacy and Safety of Givosiran (ALN-AS1) in Patients With Acute Hepatic Porphyrias (AHP)	PHASE3	COMPLETED
Fluorescence-guided Resection of Malignant Gliomas With 5-Aminolevulinic Acid	PHASE3	COMPLETED
Metvix PDT Versus Vehicle PDT With Aktilite CL128 Lamp in Patients With Actinic Keratosis on the Face and Scalp	PHASE3	COMPLETED
A Clinical Trial for Treatment of Aromatic L-amino Acid Decarboxylase (AADC) Deficiency Using AAV2-hAADC - An Expansion	PHASE2	COMPLETED
A Study of the Specificity and Sensitivity of 5-ALA Fluorescence in Malignant Brain Tumors	PHASE1/PHASE2	WITHDRAWN
A Phase I/II Clinical Trial for Treatment of Aromatic L-amino Acid Decarboxylase (AADC) Deficiency Using AAV2-hAADC	PHASE1/PHASE2	COMPLETED
Controlled Trial of Panhematin in Treatment of Acute Attacks of Porphyria	PHASE2	COMPLETED
Photodynamic Therapy Using Aminolevulinic Acid in Treating Patients With Skin Cancer	PHASE2	UNKNOWN
Maximal Use Systemic Exposure (MUSE) Study of Levulan Kerastick	PHASE2	COMPLETED
Efficacy of Sunlight Activated Synthetic Porphyrin in COVID-19 Infected Patients	PHASE1	UNKNOWN
Daylight Photodynamic Therapy for Actinic Keratosis	PHASE1	COMPLETED
Fluorescence Guided Resection of Brain Tumors	PHASE1	COMPLETED
Fluorescent Aided Resection and Evaluation of Soft Tissue Sarcomas (FLARES)	PHASE1	WITHDRAWN
Fluorescence-Guided Imaging of Brain Tumors: A Safety Study Using SBK2-ICG	PHASE1	NOT_YET_RECRUITING
Use Of The Dietary Supplement 5-ALA And Its Relationship With Sleep And Mood	nan	COMPLETED
Prevalence of Acute Hepatic Porphyria	nan	COMPLETED
Study of Nutritional Factors in Porphyria	nan	COMPLETED
Observational Study of Acute Intermittent Porphyria Patients	nan	COMPLETED
Longitudinal Study of the Porphyrias	nan	RECRUITING
Use of 5-Aminolevulinic Acid to Assess Bone and Tissue Profusion in Orthopaedic Infection Patients	nan	WITHDRAWN
Erythropoietic Protoporphyrias: Studies of the Natural History, Genotype-Phenotype Correlations, and Psychosocial Impact	nan	COMPLETED
Lysine Oxidation in Response to Arginine Supplementation	nan	COMPLETED
Photodynamic Therapy Incubation Times for Actinic Keratosis	nan	ACTIVE_NOT_RECRUITING
Clinical Diagnosis of Acute Porphyria	nan	COMPLETED
Conventional Photodynamic Therapy vs. Painless Photodynamic Therapy for Actinic Keratosis	nan	UNKNOWN
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
Identification of Acute Intermittent Porphyria Modifying Genes	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a ALAD binder may also engage these)

Protein	Name	Similarity
Q5R971	—	1.000	Q5R971 →
Q60HH9	—	1.000	Q60HH9 →
P06214	—	1.000	P06214 →
Q58DK5	—	1.000	Q58DK5 →
P78974	—	0.999	P78974 →
O42768	—	0.999	O42768 →
P43087	—	0.998	P43087 →
Q55E06	—	0.998	Q55E06 →
Q9K8G2	—	0.998	Q9K8G2 →
P10518	—	0.997	P10518 →
P43210	—	0.996	P43210 →
P0ACB2	—	0.996	P0ACB2 →
P77923	—	0.995	P77923 →
P64334	—	0.995	P64334 →
P64335	—	0.995	P64335 →
P0C1R9	—	0.995	P0C1R9 →
Q2FXR3	—	0.994	Q2FXR3 →
O84638	—	0.994	O84638 →
Q6GG37	—	0.994	Q6GG37 →
Q750E0	—	0.994	Q750E0 →
O26839	—	0.994	O26839 →
P42504	—	0.994	P42504 →
P05063	—	0.992	P05063 →
C5D7U9	—	0.991	C5D7U9 →
P05373	—	0.991	P05373 →
P77969	—	0.991	P77969 →
Q9PLU4	—	0.991	Q9PLU4 →
B4UDM7	—	0.990	B4UDM7 →
A1SVJ9	—	0.990	A1SVJ9 →
Q31UF9	—	0.990	Q31UF9 →