Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 8/20 | 0.35 |
| ▸ | PDE2A | O00408 | 8/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28166130 | 0.79 | OPRL1 (0.35) | OPRL1PDE2AGPR119 | |
| SCHEMBL3586405 | 0.77 | ALDH1A1 (0.46) | OPRL1 | |
| SCHEMBL16962258 | 0.77 | OPRL1 (0.37) | OPRL1 | |
| SCHEMBL16957741 | 0.77 | OPRL1 (0.37) | OPRL1PDE2A | |
| SCHEMBL17914538 | 0.73 | PDE2A (0.44) | OPRL1PDE2AGPR139 | |
| SCHEMBL24666020 | 0.71 | ALDH1A1 (0.49) | OPRL1 | |
| SCHEMBL29820680 | 0.71 | ALDH1A1 (0.49) | OPRL1 | |
| SCHEMBL21506773 | 0.70 | PDE2A (0.44) | OPRL1PDE2AGPR139 | |
| SCHEMBL16961849 | 0.70 | PDE2A (0.43) | OPRL1PDE2AGPR139 | |
| SCHEMBL16962148 | 0.70 | SLC6A2 (0.43) | OPRL1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016183741-A1 | PYRIMIDINONE AMIDE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-11-24 | — | — | WO | claimed |