Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 3/20 | 0.39 |
| ▸ | FRK | P42685 | 3/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | YES1 | P07947 | 2/20 | 0.39 |
| ▸ | LYN | P07948 | 2/20 | 0.39 |
| ▸ | FGR | P09769 | 2/20 | 0.39 |
| ▸ | NPY1R | P25929 | 6/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28467308 | 0.80 | DRD2 (0.40) | DRD2HTR2AHRH1KCNH2HRH3 | |
| SCHEMBL28472871 | 0.79 | KDM1A (0.41) | IGF1RDRD2HTR2AHRH1KDM1A | |
| SCHEMBL28462812 | 0.77 | KDM1A (0.47) | DRD2HTR2AHRH1L3MBTL3HRH3 | |
| SCHEMBL6266353 | 0.70 | KDM1A (0.43) | DRD2HTR2AHRH1FYNCYP3A4 | |
| SCHEMBL26234384 | 0.67 | — | — | |
| SCHEMBL22823535 | 0.67 | NPY1R (0.38) | HRH1RETABL1SRCFRK | |
| SCHEMBL20255406 | 0.66 | DRD2 (0.45) | DRD2HTR2ACYP3A4KCNH2HRH3 | |
| SCHEMBL10223659 | 0.65 | DRD2 (0.44) | DRD2NPY1RNOS3NOS1NOS2 | |
| SCHEMBL25332567 | 0.64 | NPC1 (0.32) | — | |
| SCHEMBL15956482 | 0.63 | NPY1R (0.43) | NPY1RL3MBTL3CYP3A4CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10294227-B2 | Compounds | UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2019-05-21 | — | — | US | disclosed |
| US-20180127422-A1 | COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2018-05-10 | — | — | US | disclosed |
| EP-3298015-A1 | COMPOUNDS | The University Court of the University of Edinburgh (GB) | 2018-03-28 | — | — | EP | disclosed |
| WO-2016185160-A1 | COMPOUNDS | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2016-11-24 | — | — | WO | disclosed |
| WO-2016185160-A1 | COMPOUNDS | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2016-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127422-A1 | COMPOUNDS | CBR3, OR10J3, CBR1 | IGF1R 1559/4885DRD2 1416/4885HTR2A 2684/4885 |
| US-10294227-B2 | Compounds | CBR3, OR10J3, CBR1 | IGF1R 1704/4885DRD2 1612/4885HTR2A 2810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.