Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 12/20 | 0.60 |
| ▸ | RET | P07949 | 5/20 | 0.60 |
| ▸ | MTOR | P42345 | 4/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.50 |
| ▸ | PRKDC | P78527 | 1/20 | 0.50 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 2/20 | 0.49 |
| ▸ | YES1 | P07947 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25033269 | 0.79 | MTOR (0.56) | ABL1RETMTORPIK3CDPIK3CA | |
| SCHEMBL18250076 | 0.77 | ABL1 (0.59) | ABL1RETMTORPIK3CDPIK3CA | |
| SCHEMBL22692823 | 0.77 | ABL1 (0.72) | ABL1RETMTORPIK3CDPIK3CA | |
| SCHEMBL18250077 | 0.77 | MTOR (0.54) | ABL1RETMTORPIK3CDPIK3CA | |
| SCHEMBL30877161 | 0.77 | MTOR (0.54) | ABL1RETMTORPIK3CDPIK3CA | |
| SCHEMBL18690708 | 0.76 | ABL1 (1.00) | ABL1RETMTORPIK3CDPIK3CA | |
| SCHEMBL29496415 | 0.76 | ABL1 (1.00) | ABL1RETMTORPIK3CDPIK3CA | |
| SCHEMBL18258374 | 0.73 | MTOR (0.67) | ABL1RETMTORPIK3CDPIK3CA | |
| SCHEMBL18250088 | 0.72 | PIK3CD (0.65) | ABL1RETMTORPIK3CDPIK3CA | |
| SCHEMBL20132634 | 0.71 | MTOR (0.64) | ABL1RETMTORPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10294227-B2 | Compounds | UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2019-05-21 | — | — | US | disclosed |
| US-20180127422-A1 | COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2018-05-10 | — | — | US | disclosed |
| EP-3298015-A1 | COMPOUNDS | The University Court of the University of Edinburgh (GB) | 2018-03-28 | — | — | EP | disclosed |
| WO-2016185160-A1 | COMPOUNDS | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2016-11-24 | — | — | WO | disclosed |
| WO-2016185160-A1 | COMPOUNDS | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2016-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127422-A1 | COMPOUNDS | CBR3, OR10J3, CBR1 | ABL1 269/4885RET 1817/4885MTOR 3566/4885 |
| US-10294227-B2 | Compounds | CBR3, OR10J3, CBR1 | ABL1 204/4885RET 1736/4885MTOR 3399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.