Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.36 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18238751 | 0.90 | MAP3K7 (0.46) | TDO2NTRK1GSK3BBACE1MAP3K7 | |
| SCHEMBL16945147 | 0.90 | MAP3K7 (0.46) | TDO2NTRK1GSK3BBACE1MAP3K7 | |
| SCHEMBL18250523 | 0.87 | GSK3B (0.41) | TDO2NTRK1GSK3BMAP3K7TAB1 | |
| SCHEMBL18250488 | 0.81 | AXL (0.44) | TDO2GSK3BBTKITKCYP3A4 | |
| SCHEMBL18250498 | 0.81 | GSK3B (0.42) | GSK3BMAP3K7TAB1BTK | |
| SCHEMBL18238269 | 0.77 | MAP3K7 (0.46) | TDO2NTRK1GSK3BMAP3K7TAB1 | |
| SCHEMBL16945189 | 0.77 | MAP3K7 (0.46) | TDO2NTRK1GSK3BMAP3K7TAB1 | |
| SCHEMBL18250576 | 0.75 | TDO2 (0.41) | TDO2GSK3BMAP3K7TAB1 | |
| SCHEMBL18250572 | 0.74 | KIT (0.46) | TDO2 | |
| SCHEMBL18250497 | 0.73 | SGK1 (0.46) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499551-B2 | Substituted pyrrolo[2,3-b]pyridines for treating cancer or inflammatory diseases | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-11-22 | — | — | US | disclosed |