Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | SGK1 | O00141 | 3/20 | 0.41 |
| ▸ | AXL | P30530 | 7/20 | 0.40 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18250576 | 0.88 | TDO2 (0.41) | RAB9ANPC1SMN1; SMN2AAK1SGK1 | |
| SCHEMBL18238325 | 0.88 | MAP3K7 (0.47) | ALDH1A1RAB9AMEN1NPC1MAPT | |
| SCHEMBL16945216 | 0.88 | MAP3K7 (0.47) | ALDH1A1RAB9AMEN1NPC1MAPT | |
| SCHEMBL18250494 | 0.83 | AXL (0.57) | SGK1AXLNEK1GSK3BRIPK1 | |
| SCHEMBL18250580 | 0.81 | MAP4K1 (0.43) | MAPTSGK1ABL1ITKMAP3K7 | |
| SCHEMBL18250498 | 0.80 | GSK3B (0.42) | ALDH1A1RAB9AMEN1NPC1MAPT | |
| SCHEMBL18250503 | 0.79 | CSNK1G2 (0.54) | SGK1AXLNEK1GSK3BCDC7 | |
| SCHEMBL16949043 | 0.77 | AXL (0.53) | AAK1SGK1AXLNEK1GSK3B | |
| SCHEMBL18238242 | 0.77 | AXL (0.53) | AAK1SGK1AXLNEK1GSK3B | |
| SCHEMBL18250540 | 0.77 | DRD4 (0.39) | ALDH1A1RAB9AMEN1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499551-B2 | Substituted pyrrolo[2,3-b]pyridines for treating cancer or inflammatory diseases | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-11-22 | — | — | US | disclosed |