SCHEMBL18251

SCHEMBL18251

O=c1[nH]c(NCc2ccccc2)nc2nc[nH]c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PNP P00491 1/20 0.62
XDH P47989 3/20 0.59
PI4KA P42356 2/20 0.56
PI4K2B Q8TCG2 2/20 0.56
PI4K2A Q9BTU6 2/20 0.56
PI4KB Q9UBF8 2/20 0.56
CDK1 P06493 1/20 0.55
PDE4A P27815 1/20 0.55
PDE4B Q07343 1/20 0.55
PDE4C Q08493 1/20 0.55
PDE4D Q08499 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1394088 0.99 PNP (0.61) PNPXDHPI4KAPI4K2BPI4K2A
Cyanide SCHEMBL2694132 0.96 PNP (0.58) PNPXDHPI4KAPI4K2BPI4K2A
Hydrochloric Acid SCHEMBL17186589 0.91 XDH (0.53) PNPXDHPI4KAPI4K2BPI4K2A
Piperidine SCHEMBL1938301 0.91 PNP (0.53) PNPXDHPI4KAPI4K2BPI4K2A
SCHEMBL28722094 0.89 PNP (0.51) PNPXDHPI4KAPI4K2BPI4K2A
SCHEMBL6812718 0.88 XDH (0.57) XDH
SCHEMBL17554279 0.87 XDH (0.63) XDH
SCHEMBL25269638 0.87 XDH (0.56) XDH
SCHEMBL29561480 0.87 XDH (0.56) XDH
SCHEMBL30101022 0.86 PDE9A (0.54) XDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6031 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4746918-A1 METHODS OF PREPARING SURFACE MODIFIED VIRAL CAPSIDS Borea Therapeutics S.r.l. (IT) 2026-05-27 EP claimed
WO-2026101423-A1 PHOTOSWITCHABLE CHEMICAL INDUCED DIMERIZATION SYSTEMS FOR CONTROL OF CELLULAR ACTIVITIES WITH LIGHT WU YAOWEN (SE) 2026-05-15 WO claimed
US-20260130982-A1 METHODS FOR ASSEMBLING PROTEIN-CONJUGATED NANOCARRIER VACCINES UNIV NORTHWESTERN (US) 2026-05-14 US claimed
EP-4740932-A2 COSMETIC COMPOSITION FOR SKIN IMPROVEMENT AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING SKIN DAMAGE, EACH CONTAINING HONOKIOL AND POLYOL Cosmax, Inc. (KR) 2026-05-13 EP claimed
WO-2026085618-A1 METHOD OF IMMOBILIZING CAPTURE PROBES TO SOLID PHASES FOR TARGET SUBSTANCE DETECTION YYZ PHARMATECH INC. (CA) 2026-04-30 WO claimed
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
US-20260103737-A1 ENZYMATIC METHODS TO GENERATE HIGH YIELDS OF SEQUENCE SPECIFIC RNA OLIGONUCLEOTIDES WITH EXTREME PRECISION UNIV MASSACHUSETTS (US) 2026-04-16 US claimed
EP-4716533-A2 FLUORESCENT INDICATORS FOR METAL ION DETECTION AS SUBSTRATES FOR A SELF-LABELING ENZYME Ion Biosciences (US) 2026-04-01 EP claimed
US-12569439-B2 Bottom-up assembly of synthetic extracellular vesicles MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2026-03-10 US claimed
EP-3336099-B1 METHOD FOR SELECTIVELY BINDING CELLS TO A BINDING PARTNER AND DEVICE COMPRISING CELLS KARLSRUHER INST TECHNOLOGIE (DE) 2026-03-04 EP claimed
CN-1628852-A Anti solid tumor medicine composition KONG QINGZHONG (CN) 2005-06-22 CN claimed
EP-1518854-A1 Substituted 06- benzylguanines and 7- or 9- substituted 8-aza-06-benzylguanines THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) 2005-03-30 EP claimed
CN-1527941-A By using O6Method for preparing -alkylguanine-DNA alkyltransferase ��ɣ��̬�ۺϼ������Ϲ�˾ 2004-09-08 CN claimed
US-20040115130-A1 Methods using O6 -alkyguanine-dna alkyltransferases ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) 2004-06-17 US claimed
EP-1410023-A2 METHODS USING O?6 -ALKYLGUANINE-DNA ALKYLTRANSFERASES Ecole Polytechnique Fédérale de Lausanne (CH) 2004-04-21 EP claimed
WO-2002083937-A2 METHODS USING O6-ALKYLGUANINE-DNA ALKYLTRANSFERASES ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) 2002-10-24 WO claimed
EP-1054890-A1 OLIGODEOXYRIBONUCLEOTIDES COMPRISING O6-BENZYLGUANINE AND THEIR USE THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) 2000-11-29 EP claimed
WO-1999041269-A1 OLIGODEOXYRIBONUCLEOTIDES COMPRISING O6-BENZYLGUANINE AND THEIR USE THE UNITED STATES OF AMERICA, REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1999-08-19 WO claimed
EP-0775142-A1 SUBSTITUTED O6 -BENZYLGUANINES AND 6(4)-BENZYLOXYPYRIMIDINES THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) 1997-05-28 EP claimed
WO-1996004281-A1 SUBSTITUTED O6-BENZYLGUANINES AND 6(4)-BENZYLOXYPYRIMIDINES THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1996-02-15 WO claimed