Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.55 |
| ▸ | BTK | Q06187 | 6/20 | 0.52 |
| ▸ | JAK3 | P52333 | 4/20 | 0.52 |
| ▸ | RET | P07949 | 6/20 | 0.48 |
| ▸ | ROS1 | P08922 | 6/20 | 0.48 |
| ▸ | FLT3 | P36888 | 6/20 | 0.48 |
| ▸ | EML4 | Q9HC35 | 3/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.48 |
| ▸ | VHL | P40337 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18251105 | 0.92 | EGFR (0.55) | EGFRBTKJAK3RETROS1 | |
| SCHEMBL16207100 | 0.89 | EGFR (0.67) | EGFRBTKJAK3RETROS1 | |
| SCHEMBL18251102 | 0.85 | EGFR (0.61) | EGFRBTKJAK3RETROS1 | |
| SCHEMBL16207109 | 0.84 | EGFR (0.70) | EGFRBTKJAK3RETROS1 | |
| SCHEMBL16207099 | 0.81 | EGFR (0.67) | EGFRBTKJAK3RETROS1 | |
| SCHEMBL16207074 | 0.81 | EGFR (0.77) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL16258229 | 0.80 | EGFR (0.60) | EGFRBTKJAK3RETROS1 | |
| SCHEMBL16207110 | 0.80 | EGFR (0.66) | EGFRBTKJAK3RETROS1 | |
| SCHEMBL16207093 | 0.80 | RET (0.75) | EGFRBTKJAK3RETROS1 | |
| SCHEMBL16195836 | 0.80 | RET (0.62) | EGFRRETROS1FLT3EML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805940-B1 | PYRAZINE CARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-11-23 | — | — | EP | disclosed |