SCHEMBL18252201

SCHEMBL18252201

c1ccc2c(c1)-c1ccccc1-c1cccc(-c3cccc4c3oc3ccccc34)c1-c1ccccc1-2

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 3/20 0.58
PRKDC P78527 5/20 0.46
PIK3CD O00329 1/20 0.45
PIK3CB P42338 1/20 0.45
NTRK1 P04629 1/20 0.42
PLK3 Q9H4B4 1/20 0.42
GGPS1 O95749 1/20 0.41
ATM Q13315 1/20 0.41
AHR P35869 1/20 0.41
MAOA P21397 2/20 0.40
KDM4E B2RXH2 1/20 0.40
NPC1 O15118 1/20 0.40
ALDH1A1 P00352 1/20 0.40
LMNA P02545 1/20 0.40
RAB9A P51151 1/20 0.40
HDAC8 Q9BY41 1/20 0.39
DRD4 P21917 1/20 0.38
CDC25A P30304 1/20 0.38
CDC25B P30305 1/20 0.38
CDC25C P30307 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL126542 0.92 ALOX5 (0.58) ALOX5PRKDCPIK3CDPIK3CBNTRK1
SCHEMBL12996513 0.92 ALOX5 (0.66) ALOX5PRKDCPIK3CDPIK3CBGGPS1
SCHEMBL430138 0.92 ALOX5 (0.66) ALOX5PRKDCPIK3CDPIK3CBGGPS1
SCHEMBL431458 0.92 ALOX5 (0.66) ALOX5PRKDCPIK3CDPIK3CBGGPS1
SCHEMBL20062685 0.92 ALOX5 (0.55) ALOX5PRKDCPIK3CDPIK3CBNTRK1
SCHEMBL20062682 0.92 ALOX5 (0.55) ALOX5PRKDCPIK3CDPIK3CBNTRK1
SCHEMBL18877443 0.91 ALOX5 (0.57) ALOX5PRKDCPIK3CDPIK3CBNTRK1
SCHEMBL22854844 0.91 ALOX5 (0.57) ALOX5PRKDCPIK3CDPIK3CBNTRK1
SCHEMBL20062697 0.90 ALOX5 (0.54) ALOX5PRKDCPIK3CDPIK3CBNTRK1
SCHEMBL10945864 0.90 ALOX5 (0.68) ALOX5PRKDCPIK3CDPIK3CBGGPS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10256411-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2019-04-09 US disclosed
US-20170077409-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2017-03-16 US disclosed
US-20170077409-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2017-03-16 US disclosed
US-20160343951-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2016-11-24 US disclosed
US-20160343951-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2016-11-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160343951-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OSBP, OSBPL3, OSBPL8 ALOX5 590/4885PRKDC 2829/4885PIK3CD 1416/4885
US-20170077409-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OSBP, OSBPL3, OSBPL8 ALOX5 590/4885PRKDC 2829/4885PIK3CD 1416/4885
US-10256411-B2 Organic electroluminescent materials and devices OSBP, OSBPL3, OSBPL8 ALOX5 590/4885PRKDC 2829/4885PIK3CD 1416/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.