Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLPP | Q16740 | 6/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.79 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.79 |
| ▸ | DRD2 | P14416 | 1/20 | 0.79 |
| ▸ | DRD3 | P35462 | 1/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29595454 | 1.00 | CLPP (0.79) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| SCHEMBL18254980 | 1.00 | CLPP (0.79) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| SCHEMBL18254991 | 0.94 | CLPP (0.89) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| SCHEMBL18254967 | 0.94 | CLPP (0.69) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| SCHEMBL18254995 | 0.89 | CLPP (0.82) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| SCHEMBL18254966 | 0.89 | CLPP (0.79) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| SCHEMBL18254974 | 0.89 | CLPP (0.79) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| SCHEMBL18255101 | 0.89 | CLPP (0.82) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| SCHEMBL18254965 | 0.89 | CLPP (0.65) | CLPPCYP3A4GPR132CYP2D6DRD2 | |
| SCHEMBL18254939 | 0.89 | CLPP (0.66) | CLPPCYP3A4GPR132CYP2D6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180141946-A1 | Imidazo-pyrimidone Compounds, and Preparation Method and Application Thereof | Madera Therapeutics, LLC | 2018-05-24 | — | — | US | disclosed |
| US-20180141946-A1 | Imidazo-pyrimidone Compounds, and Preparation Method and Application Thereof | Madera Therapeutics, LLC | 2018-05-24 | — | — | US | disclosed |
| WO-2016184437-A1 | IMIDAZO-PYRIMIDONE COMPOUNDS, AND PREPARATION METHOD AND APPLICATION THEREOF | 南京盖特医药技术有限公司 | 2016-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141946-A1 | Imidazo-pyrimidone Compounds, and Preparation Method and Application Thereof | TNFRSF1A, TNF, TNFRSF9 | CLPP 1046/4885CYP3A4 858/4885GPR132 1981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.