Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.81 |
| ▸ | CNR1 | P21554 | 3/20 | 0.60 |
| ▸ | PLCD1 | P51178 | 1/20 | 0.60 |
| ▸ | F2 | P00734 | 1/20 | 0.60 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.60 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.60 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.60 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | IDE | P14735 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | CNR2 | P34972 | 2/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2768198 | 1.00 | TDP1 (0.81) | TDP1CNR1PLCD1F2PRSS1 | |
| SCHEMBL19959667 | 1.00 | TDP1 (0.81) | TDP1CNR1PLCD1F2PRSS1 | |
| SCHEMBL18779801 | 0.92 | TDP1 (0.78) | TDP1PLCD1F2PRSS1PRSS2 | |
| SCHEMBL16141189 | 0.91 | TDP1 (0.97) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL19409007 | 0.91 | TDP1 (0.73) | TDP1CNR1PLCD1F2PRSS1 | |
| SCHEMBL19380670 | 0.91 | TDP1 (0.73) | TDP1CNR1PLCD1F2PRSS1 | |
| SCHEMBL13497919 | 0.91 | TDP1 (0.67) | TDP1CNR1PLCD1F2PRSS1 | |
| SCHEMBL12675370 | 0.91 | TDP1 (0.67) | TDP1CNR1PLCD1F2PRSS1 | |
| SCHEMBL10047701 | 0.90 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL565879 | 0.90 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016187544-A1 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING CANCER | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-11-24 | — | — | WO | disclosed |