Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRL | P40313 | 2/20 | 0.74 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.74 |
| ▸ | PSMB5 | P28074 | 15/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.73 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.73 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.73 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.73 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.73 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.73 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.73 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.73 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.73 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.73 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.73 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.73 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.73 |
| ▸ | CTSB | P07858 | 1/20 | 0.73 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.73 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20825234 | 1.00 | CTRL (0.74) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL18257556 | 1.00 | CTRL (0.74) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL21367483 | 1.00 | CTRL (0.74) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL18257499 | 1.00 | CTRL (0.74) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL18257507 | 1.00 | CTRL (0.74) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL20825236 | 1.00 | CTRL (0.74) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL18257541 | 1.00 | CTRL (0.74) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL21367439 | 0.94 | TMPRSS11D (0.65) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL23616283 | 0.93 | TMPRSS11D (0.76) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL21229438 | 0.93 | TMPRSS11D (0.76) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3297678-B1 | AN IMPROVED PROCESSES FOR THE PREPARATION OF CARFILZOMIB OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | LAURUS LABS LTD (IN) | 2021-07-07 | — | — | EP | disclosed |
| WO-2016185450-A1 | AN IMPROVED PROCESSES FOR THE PREPARATION OF CARFILZOMIB OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | LAURUS LABS PRIVATE LIMITED (IN) | 2016-11-24 | — | — | WO | disclosed |