Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS11D | O60235 | 2/20 | 0.76 |
| ▸ | CTRL | P40313 | 2/20 | 0.76 |
| ▸ | PSMB5 | P28074 | 14/20 | 0.75 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.75 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.75 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.75 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.75 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.75 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.75 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.75 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.75 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.75 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.75 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.75 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.75 |
| ▸ | CTSB | P07858 | 1/20 | 0.75 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.75 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17629505 | 1.00 | TMPRSS11D (0.76) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL8080980 | 1.00 | TMPRSS11D (0.76) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL10083436 | 1.00 | TMPRSS11D (0.76) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL17629503 | 1.00 | TMPRSS11D (0.76) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL19762063 | 1.00 | TMPRSS11D (0.76) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL23616283 | 1.00 | TMPRSS11D (0.76) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL17452274 | 0.95 | CTRL (0.70) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL20825236 | 0.93 | CTRL (0.74) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL18257499 | 0.93 | CTRL (0.74) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 | |
| SCHEMBL21367483 | 0.93 | CTRL (0.74) | TMPRSS11DCTRLPSMB5PSMB8CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2207791-B2 | CRYSTALLINE PEPTIDE EPOXY KETONE PROTEASE INHIBITORS AND THE SYNTHESIS OF AMINO ACID KETO-EPOXIDES | ONYX THERAPEUTICS INC (US) | 2019-08-07 | — | — | EP | disclosed |