Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.55 |
| ▸ | TUBB | P07437 | 5/20 | 0.55 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.55 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.55 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.55 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.55 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.55 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.55 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.55 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.55 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.55 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.55 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.55 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.55 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29813332 | 1.00 | LMNA (0.69) | LMNAPOLBHPGDBLMSMN1; SMN2 | |
| SCHEMBL18258412 | 0.92 | POLB (0.66) | LMNAPOLBHPGDBLMSMN1; SMN2 | |
| SCHEMBL29813324 | 0.92 | POLB (0.66) | LMNAPOLBHPGDBLMSMN1; SMN2 | |
| SCHEMBL18258435 | 0.90 | LMNA (0.84) | LMNAPOLBHPGDBLMSMN1; SMN2 | |
| SCHEMBL29813340 | 0.90 | LMNA (0.84) | LMNAPOLBHPGDBLMSMN1; SMN2 | |
| SCHEMBL18258493 | 0.89 | LMNA (0.55) | LMNAPOLBHPGDBLMSMN1; SMN2 | |
| SCHEMBL29813158 | 0.89 | LMNA (0.55) | LMNAPOLBHPGDBLMSMN1; SMN2 | |
| SCHEMBL29813376 | 0.89 | SMN1; SMN2 (0.54) | LMNAPOLBHPGDBLMSMN1; SMN2 | |
| SCHEMBL18258496 | 0.89 | SMN1; SMN2 (0.54) | LMNAPOLBHPGDBLMSMN1; SMN2 | |
| SCHEMBL18258485 | 0.88 | SMN1; SMN2 (0.54) | LMNAPOLBHPGDBLMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3298005-B1 | ANTI-CANCER COMPOUNDS | UNIV CALIFORNIA (US) | 2024-01-24 | — | — | EP | disclosed |
| US-11708352-B2 | Anti-cancer compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-07-25 | — | — | US | disclosed |
| US-11149025-B2 | Anti-cancer compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-10-19 | — | — | US | disclosed |
| US-20210009562-A1 | ANTI-CANCER COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2021-01-14 | — | — | US | disclosed |
| US-10562886-B2 | Anti-cancer compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-02-18 | — | — | US | disclosed |
| US-10562886-B2 | Anti-cancer compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-02-18 | — | — | US | disclosed |
| US-20180354932-A1 | ANTI-CANCER COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2018-12-13 | — | — | US | disclosed |
| WO-2016187620-A2 | ANTI-CANCER COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10562886-B2 | Anti-cancer compounds | TP53, VHL, BAD | LMNA 2654/4885POLB 714/4885HPGD 1848/4885 |
| US-20180354932-A1 | ANTI-CANCER COMPOUNDS | TP53, VHL, BAD | LMNA 2654/4885POLB 714/4885HPGD 1848/4885 |
| US-20210009562-A1 | ANTI-CANCER COMPOUNDS | TP53, VHL, BAD | LMNA 2654/4885POLB 714/4885HPGD 1848/4885 |
| US-11708352-B2 | Anti-cancer compounds | TP53, VHL, BAD | LMNA 2654/4885POLB 714/4885HPGD 1848/4885 |
| US-11149025-B2 | Anti-cancer compounds | TP53, VHL, BAD | LMNA 2654/4885POLB 714/4885HPGD 1848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.