Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.83 |
| ▸ | HMGCR | P04035 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.40 |
| ▸ | CPT2 | P23786 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL7369132 | 1.00 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28074368 | 1.00 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28314073 | 1.00 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL8146438 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL20917177 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL13684439 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL21494573 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL21753855 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL372535 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL600583 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 237 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7355029-B2 | Genes encoding carbon metabolism and energy-producing proteins | BASF AG (DE) | 2008-04-08 | — | — | US | claimed |
| WO-2024042318-A1 | CHIMERIC ANTIGEN RECEPTOR (CAR) TO A TCR BETA-CHAIN VARIABLE REGION | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2024-02-29 | — | — | WO | disclosed |
| EP-4217392-A1 | ZIP12 ANTIBODY | IP2IPO Innovations Limited (GB) | 2023-08-02 | — | — | EP | disclosed |
| WO-2020157487-A9 | GENETIC CONSTRUCT AND USES THEREOF | THE UNIVERSITY OF NOTTINGHAM (GB) | 2022-07-14 | — | — | WO | disclosed |
| WO-2022064216-A1 | ZIP12 ANTIBODY | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2022-03-31 | — | — | WO | disclosed |
| EP-3918064-A2 | GENETIC CONSTRUCT AND USES THEREOF | The University of Nottingham (GB) | 2021-12-08 | — | — | EP | disclosed |
| EP-3833330-A1 | METHOD FOR PREPARING LIPOSOMES | The University Of Greenwich (GB) | 2021-06-16 | — | — | EP | disclosed |
| EP-3809839-A1 | POLYNUCLEOTIDE | Imperial College of Science, Technology and Medicine (GB) | 2021-04-28 | — | — | EP | disclosed |
| WO-2020157487-A2 | GENETIC CONSTRUCT AND USES THEREOF | THE UNIVERSITY OF NOTTINGHAM (GB) | 2020-08-06 | — | — | WO | disclosed |
| EP-3630961-A1 | GENETIC CONSTRUCT | McDonald, Michael (GB) | 2020-04-08 | — | — | EP | disclosed |
| EP-1007726-A1 | METHOD AND COMPOSITIONS FOR CONTROLLING GENE EXPRESSION | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2000-06-14 | — | — | EP | disclosed |
| WO-2000020579-A1 | SPLICED FORM OF ERBB-2/NEU ONCOGENE | MCMASTER UNIVERSITY (CA) | 2000-04-13 | — | — | WO | disclosed |
| EP-0977857-A1 | HUMAN C-MAF COMPOSITIONS AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2000-02-09 | — | — | EP | disclosed |
| EP-0961828-A1 | CIITA-INTERACTING PROTEINS AND METHODS OF USE THEREFOR | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1999-12-08 | — | — | EP | disclosed |
| WO-1999047686-A2 | HUMAN MEKK PROTEINS, CORRESPONDING NUCLEIC ACID MOLECULES, AND USES THEREFOR | CADUS PHARMACEUTICAL CORPORATION (US) | 1999-09-23 | — | — | WO | disclosed |
| WO-1999043808-A1 | HUMAN C-MAF COMPOSITIONS AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1999-09-02 | — | — | WO | disclosed |
| WO-1999024570-A1 | CIITA-INTERACTING PROTEINS AND METHODS OF USE THEREFOR | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1999-05-20 | — | — | WO | disclosed |
| WO-1999019484-A1 | T CELL RECEPTOR-ASSOCIATED MOLECULES (TRAMS) AND METHODS OF USE THEREFOR | BASF AKTIENGESELLSCHAFT (US) | 1999-04-22 | — | — | WO | disclosed |
| WO-1999013061-A1 | PLUS END-DIRECTED MICROTUBULE MOTOR REQUIRED FOR CHROMOSOME CONGRESSION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-03-18 | — | — | WO | disclosed |
| WO-1997046713-A1 | METHOD AND COMPOSITIONS FOR CONTROLLING GENE EXPRESSION | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1997-12-11 | — | — | WO | disclosed |